THSG counteracts microglial glycolytic reprogramming and neuronal necroptosis both in vivo and in vitro under conditions of neuroinflammation
Abstract Microglial activation, driven by a metabolic shift towards aerobic glycolysis, is implicated in neuroinflammation and neurological disorders like depression. THSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside), derived from Polygonum multiflorum, exhibits anti-inflammatory and neuroprote...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-05994-y |
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