The effect of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats
Background and Aim: Cadmium, a heavy and toxic metal, is a known environmental pollutant with teratogenic effects. This study aims to assess the influence of a course of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testi...
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Kashan University of Medical Sciences
2024-04-01
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| Series: | مجله علوم پزشکی فیض (پیوسته) |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-5060-en.pdf |
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| author | Amir Delshad Maryam sadat Dashti Nasrin Heidarieh Fateme Movahedi Fard |
| author_facet | Amir Delshad Maryam sadat Dashti Nasrin Heidarieh Fateme Movahedi Fard |
| author_sort | Amir Delshad |
| collection | DOAJ |
| description | Background and Aim: Cadmium, a heavy and toxic metal, is a known environmental pollutant with teratogenic effects. This study aims to assess the influence of a course of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats.
Methods: In this experimental study, 48 12-week-old adult male Wistar rats, weighing 250 ± 30 grams, were divided into six equal groups: healthy control, exercise, cadmium (Cd), exercise-Cd, ginger-50 Cd, and ginger-100 Cd. The rats received 3 mg of cadmium chloride and hydroalcoholic extract of ginger at a rate of 50 or 100 mg/kg of body weight. The training protocol included running on a treadmill with an intensity of 27 m/min. After a 5-week period, the rats were anesthetized with diethyl ether, and their testis tissue was evaluated to determine the quantity of FGF-1 and VEGF.
Results: The aerobic training group showed a significant increase (P=0.004) in the expression of VEGF and FGF-2 genes in testicular tissue compared to the control group. Conversely, the cadmium group displayed a significant decrease (P=0.001) in the expression of these genes. The ginger 100 and 50 + cadmium group did not show a significant change in VEGF and FGF-2 gene expression compared to the control group.
Conclusion: Cadmium exposure resulted in decreased VEGF and FGF-2 gene expression in testicular tissue, while exercise led to an increase. Additionally, ginger consumption appears to mitigate cadmium-induced tissue damage, although it does not increase the expression of VEGF and FGF-2 genes. |
| format | Article |
| id | doaj-art-68c3e8e8fb324f869041d7fb4eee733e |
| institution | DOAJ |
| issn | 3060-5806 3060-5814 |
| language | fas |
| publishDate | 2024-04-01 |
| publisher | Kashan University of Medical Sciences |
| record_format | Article |
| series | مجله علوم پزشکی فیض (پیوسته) |
| spelling | doaj-art-68c3e8e8fb324f869041d7fb4eee733e2025-08-20T02:51:19ZfasKashan University of Medical Sciencesمجله علوم پزشکی فیض (پیوسته)3060-58063060-58142024-04-01282159166The effect of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar ratsAmir Delshad0Maryam sadat Dashti1Nasrin Heidarieh2Fateme Movahedi Fard3 Department of Sports Sciences, Faculty of Literature and Humanities, University of Qom, Qom, Iran Department of Sports Sciences, Faculty of Physical Education and Sports Sciences, Mazandaran University, Iran Department of Biology, Faculty of Basic Sciences, Qom Branch, Islamic Azad University, Qom, Iran Master of Applied Sports Physiology, Tolo Mehr University, Qom, Iran Background and Aim: Cadmium, a heavy and toxic metal, is a known environmental pollutant with teratogenic effects. This study aims to assess the influence of a course of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats. Methods: In this experimental study, 48 12-week-old adult male Wistar rats, weighing 250 ± 30 grams, were divided into six equal groups: healthy control, exercise, cadmium (Cd), exercise-Cd, ginger-50 Cd, and ginger-100 Cd. The rats received 3 mg of cadmium chloride and hydroalcoholic extract of ginger at a rate of 50 or 100 mg/kg of body weight. The training protocol included running on a treadmill with an intensity of 27 m/min. After a 5-week period, the rats were anesthetized with diethyl ether, and their testis tissue was evaluated to determine the quantity of FGF-1 and VEGF. Results: The aerobic training group showed a significant increase (P=0.004) in the expression of VEGF and FGF-2 genes in testicular tissue compared to the control group. Conversely, the cadmium group displayed a significant decrease (P=0.001) in the expression of these genes. The ginger 100 and 50 + cadmium group did not show a significant change in VEGF and FGF-2 gene expression compared to the control group. Conclusion: Cadmium exposure resulted in decreased VEGF and FGF-2 gene expression in testicular tissue, while exercise led to an increase. Additionally, ginger consumption appears to mitigate cadmium-induced tissue damage, although it does not increase the expression of VEGF and FGF-2 genes.http://feyz.kaums.ac.ir/article-1-5060-en.pdfaerobic exercisecadmiumfgf-2ginger extractinfertilityvegf |
| spellingShingle | Amir Delshad Maryam sadat Dashti Nasrin Heidarieh Fateme Movahedi Fard The effect of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats مجله علوم پزشکی فیض (پیوسته) aerobic exercise cadmium fgf-2 ginger extract infertility vegf |
| title | The effect of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats |
| title_full | The effect of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats |
| title_fullStr | The effect of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats |
| title_full_unstemmed | The effect of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats |
| title_short | The effect of aerobic exercise and ginger hydroalcoholic extract on the expression of VEGF and FGF-2 in cadmium chloride-induced infertile testis tissue in adult male Wistar rats |
| title_sort | effect of aerobic exercise and ginger hydroalcoholic extract on the expression of vegf and fgf 2 in cadmium chloride induced infertile testis tissue in adult male wistar rats |
| topic | aerobic exercise cadmium fgf-2 ginger extract infertility vegf |
| url | http://feyz.kaums.ac.ir/article-1-5060-en.pdf |
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