Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms
Evidences have shown the presence of multipotent stem cells (SCs) at sites of arterial aneurysms: they can differentiate into smooth muscle cells (SMCs) and are activated after residing in a quiescent state in the vascular wall. Recent studies have implicated the role of matrix metalloproteinases in...
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Format: | Article |
Language: | English |
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Wiley
2015-01-01
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Series: | Stem Cells International |
Online Access: | http://dx.doi.org/10.1155/2015/434962 |
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author | Bruno Amato Rita Compagna Maurizio Amato Raffaele Grande Lucia Butrico Alessio Rossi Agostino Naso Michele Ruggiero Stefano de Franciscis Raffaele Serra |
author_facet | Bruno Amato Rita Compagna Maurizio Amato Raffaele Grande Lucia Butrico Alessio Rossi Agostino Naso Michele Ruggiero Stefano de Franciscis Raffaele Serra |
author_sort | Bruno Amato |
collection | DOAJ |
description | Evidences have shown the presence of multipotent stem cells (SCs) at sites of arterial aneurysms: they can differentiate into smooth muscle cells (SMCs) and are activated after residing in a quiescent state in the vascular wall. Recent studies have implicated the role of matrix metalloproteinases in the pathogenesis of arterial aneurysms: in fact the increased synthesis of MMPs by arterial SMCs is thought to be a pivotal mechanism in aneurysm formation. The factors and signaling pathways involved in regulating wall resident SC recruitment, survival, proliferation, growth factor production, and differentiation may be also related to selective expression of different MMPs. This review explores the relationship between adult vascular wall resident multipotent vascular SCs, MMPs, and arterial aneurysms. |
format | Article |
id | doaj-art-68be89e2762546a4a4b10072c43c256f |
institution | Kabale University |
issn | 1687-966X 1687-9678 |
language | English |
publishDate | 2015-01-01 |
publisher | Wiley |
record_format | Article |
series | Stem Cells International |
spelling | doaj-art-68be89e2762546a4a4b10072c43c256f2025-02-03T05:43:51ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/434962434962Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial AneurysmsBruno Amato0Rita Compagna1Maurizio Amato2Raffaele Grande3Lucia Butrico4Alessio Rossi5Agostino Naso6Michele Ruggiero7Stefano de Franciscis8Raffaele Serra9Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyDepartment of Clinical Medicine and Surgery, University of Naples “Federico II”, 80100 Naples, ItalyDepartment of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medicine and Health Sciences, University of Molise, 88100 Campobasso, ItalyDepartment of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, ItalyInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyEvidences have shown the presence of multipotent stem cells (SCs) at sites of arterial aneurysms: they can differentiate into smooth muscle cells (SMCs) and are activated after residing in a quiescent state in the vascular wall. Recent studies have implicated the role of matrix metalloproteinases in the pathogenesis of arterial aneurysms: in fact the increased synthesis of MMPs by arterial SMCs is thought to be a pivotal mechanism in aneurysm formation. The factors and signaling pathways involved in regulating wall resident SC recruitment, survival, proliferation, growth factor production, and differentiation may be also related to selective expression of different MMPs. This review explores the relationship between adult vascular wall resident multipotent vascular SCs, MMPs, and arterial aneurysms.http://dx.doi.org/10.1155/2015/434962 |
spellingShingle | Bruno Amato Rita Compagna Maurizio Amato Raffaele Grande Lucia Butrico Alessio Rossi Agostino Naso Michele Ruggiero Stefano de Franciscis Raffaele Serra Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms Stem Cells International |
title | Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms |
title_full | Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms |
title_fullStr | Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms |
title_full_unstemmed | Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms |
title_short | Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms |
title_sort | adult vascular wall resident multipotent vascular stem cells matrix metalloproteinases and arterial aneurysms |
url | http://dx.doi.org/10.1155/2015/434962 |
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