Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives
A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were act...
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| Format: | Article |
| Language: | English |
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University of Tehran
2020-04-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Subjects: | |
| Online Access: | https://jsciences.ut.ac.ir/article_74789_4ef3a45675e366fcbdf240d9dd9c8cbd.pdf |
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| author | M. Yazdanian B Zihayat MH Moshafi A Khodadadi A Peimani A Shamsaddini M Nourhashemi Alireza Foroumadi |
| author_facet | M. Yazdanian B Zihayat MH Moshafi A Khodadadi A Peimani A Shamsaddini M Nourhashemi Alireza Foroumadi |
| author_sort | M. Yazdanian |
| collection | DOAJ |
| description | A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were active against Gram-positive bacteria, determined by MIC method. Among them, compounds 6a, 6b and 6d exhibited strong anti-bacterial effects against the Gram-positive bacteria. The oxidation of synthesized compounds to sulfinyl and sulfonyl bearing analogues did not improve the activity. |
| format | Article |
| id | doaj-art-68bdfd54b11344e2b140f7b662c86953 |
| institution | OA Journals |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-68bdfd54b11344e2b140f7b662c869532025-08-20T02:25:54ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69142020-04-0131214715310.22059/jsciences.2020.283309.100741974789Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole DerivativesM. Yazdanian0B Zihayat1MH Moshafi2A Khodadadi3A Peimani4A Shamsaddini5M Nourhashemi6Alireza Foroumadi7Kerman University of Medical SciencesKerman University of Medical SciencesKerman University of Medical SciencesKerman University of Medical SciencesKerman University of Medical SciencesKerman University of Medical SciencesTehran University of Medical SciencesTehran University of Medical SciencesA new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were active against Gram-positive bacteria, determined by MIC method. Among them, compounds 6a, 6b and 6d exhibited strong anti-bacterial effects against the Gram-positive bacteria. The oxidation of synthesized compounds to sulfinyl and sulfonyl bearing analogues did not improve the activity.https://jsciences.ut.ac.ir/article_74789_4ef3a45675e366fcbdf240d9dd9c8cbd.pdf1,3,4-thiadiazoleantibacterial activitysynthesis |
| spellingShingle | M. Yazdanian B Zihayat MH Moshafi A Khodadadi A Peimani A Shamsaddini M Nourhashemi Alireza Foroumadi Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives Journal of Sciences, Islamic Republic of Iran 1,3,4-thiadiazole antibacterial activity synthesis |
| title | Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives |
| title_full | Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives |
| title_fullStr | Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives |
| title_full_unstemmed | Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives |
| title_short | Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives |
| title_sort | synthesis and in vitro anti bacterial activity of 2 5 nitro 2 heteroaryl 1 3 4 thiadiazole derivatives |
| topic | 1,3,4-thiadiazole antibacterial activity synthesis |
| url | https://jsciences.ut.ac.ir/article_74789_4ef3a45675e366fcbdf240d9dd9c8cbd.pdf |
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