Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes
Serum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity. The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB). Fifty-seven patients with type 2 diabetes underwent RYGB. Serum levels of B...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/681205 |
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| author | Mee Kyoung Kim Eun-Hee Jang Oak-Kee Hong Hyun-Ji Chun Soon-Jib Yoo Ki-Hyun Baek Wook Kim Eung Kook Kim Ki-Ho Song Hyuk-Sang Kwon |
| author_facet | Mee Kyoung Kim Eun-Hee Jang Oak-Kee Hong Hyun-Ji Chun Soon-Jib Yoo Ki-Hyun Baek Wook Kim Eung Kook Kim Ki-Ho Song Hyuk-Sang Kwon |
| author_sort | Mee Kyoung Kim |
| collection | DOAJ |
| description | Serum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity. The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB). Fifty-seven patients with type 2 diabetes underwent RYGB. Serum levels of BMP-4 and various inflammatory markers, including high-sensitivity C-reactive protein (hsCRP), free fatty acids (FFAs), and plasminogen activator inhibitor- (PAI-) 1, were measured before and 12 months after RYGB. Remission was defined as glycated hemoglobin <6.5% for at least 1 year in the absence of medications. Levels of PAI-1, hsCRP, and FFAs were significantly decreased at 1 year after RYGB. BMP-4 levels were also significantly lower at 1 year after RYGB than at baseline (P=0.024). Of the 57 patients, 40 (70%) had diabetes remission at 1 year after surgery (remission group). Compared with patients in the nonremission group, patients in the remission group had lower PAI-1 levels and smaller visceral fat areas at baseline. There was a difference in the change in the BMP-4 level according to remission status. Our data demonstrate a significant beneficial effect of bariatric surgery on established cardiovascular risk factors and a reduction in chronic nonspecific inflammation after surgery. |
| format | Article |
| id | doaj-art-68bbcb42ebcd443981a8c3dff226f7e4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-68bbcb42ebcd443981a8c3dff226f7e42025-02-03T01:21:54ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/681205681205Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 DiabetesMee Kyoung Kim0Eun-Hee Jang1Oak-Kee Hong2Hyun-Ji Chun3Soon-Jib Yoo4Ki-Hyun Baek5Wook Kim6Eung Kook Kim7Ki-Ho Song8Hyuk-Sang Kwon9Department of Internal Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 62 Yeouido-dong Youngdeungpo-gu, Seoul 150-713, Republic of KoreaDepartment of Internal Medicine, Hando Hospital, Seonbu 1-dong, Danwon-gu, Ansan 425-140, Republic of KoreaDepartment of Internal Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 62 Yeouido-dong Youngdeungpo-gu, Seoul 150-713, Republic of KoreaDepartment of Internal Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 62 Yeouido-dong Youngdeungpo-gu, Seoul 150-713, Republic of KoreaDepartment of Internal Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 62 Yeouido-dong Youngdeungpo-gu, Seoul 150-713, Republic of KoreaDepartment of Internal Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 62 Yeouido-dong Youngdeungpo-gu, Seoul 150-713, Republic of KoreaDepartment of Surgery, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Surgery, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Internal Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 62 Yeouido-dong Youngdeungpo-gu, Seoul 150-713, Republic of KoreaDepartment of Internal Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 62 Yeouido-dong Youngdeungpo-gu, Seoul 150-713, Republic of KoreaSerum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity. The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB). Fifty-seven patients with type 2 diabetes underwent RYGB. Serum levels of BMP-4 and various inflammatory markers, including high-sensitivity C-reactive protein (hsCRP), free fatty acids (FFAs), and plasminogen activator inhibitor- (PAI-) 1, were measured before and 12 months after RYGB. Remission was defined as glycated hemoglobin <6.5% for at least 1 year in the absence of medications. Levels of PAI-1, hsCRP, and FFAs were significantly decreased at 1 year after RYGB. BMP-4 levels were also significantly lower at 1 year after RYGB than at baseline (P=0.024). Of the 57 patients, 40 (70%) had diabetes remission at 1 year after surgery (remission group). Compared with patients in the nonremission group, patients in the remission group had lower PAI-1 levels and smaller visceral fat areas at baseline. There was a difference in the change in the BMP-4 level according to remission status. Our data demonstrate a significant beneficial effect of bariatric surgery on established cardiovascular risk factors and a reduction in chronic nonspecific inflammation after surgery.http://dx.doi.org/10.1155/2013/681205 |
| spellingShingle | Mee Kyoung Kim Eun-Hee Jang Oak-Kee Hong Hyun-Ji Chun Soon-Jib Yoo Ki-Hyun Baek Wook Kim Eung Kook Kim Ki-Ho Song Hyuk-Sang Kwon Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes International Journal of Endocrinology |
| title | Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes |
| title_full | Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes |
| title_fullStr | Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes |
| title_full_unstemmed | Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes |
| title_short | Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes |
| title_sort | changes in serum levels of bone morphogenic protein 4 and inflammatory cytokines after bariatric surgery in severely obese korean patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2013/681205 |
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