Case Report: Cutaneous T-cell lymphoma associated with biologic therapy: three cases and a literature review
Cutaneous T-cell lymphoma (CTCL) often presents with early-stage clinical features indistinguishable from atopic dermatitis (AD), posing significant diagnostic challenges. Recent studies have highlighted cases where patients initially diagnosed with AD and treated with biologic agents were subsequen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1544912/full |
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| author | Tingting Li Guanyu Wang Chunlei Zhang Wenhui Wang Chunting Li Yimeng Wang |
| author_facet | Tingting Li Guanyu Wang Chunlei Zhang Wenhui Wang Chunting Li Yimeng Wang |
| author_sort | Tingting Li |
| collection | DOAJ |
| description | Cutaneous T-cell lymphoma (CTCL) often presents with early-stage clinical features indistinguishable from atopic dermatitis (AD), posing significant diagnostic challenges. Recent studies have highlighted cases where patients initially diagnosed with AD and treated with biologic agents were subsequently reclassified as having CTCL, though the nature of this relationship remains poorly understood. In this report, we present two cases of mycosis fungoides and one case of Sézary syndrome (SS), all initially diagnosed as AD and treated with biologic agents, including dupilumab. Furthermore, we conducted a literature review exploring potential associations between AD, biologic agents, and CTCL. Our objective is to improve clinicians’ ability to differentiate between AD and CTCL and to provide evidence supporting a possible association between biologic treatments and CTCL. Our findings highlight the need for heightened clinical vigilance and the routine use of skin biopsy in refractory eczematous presentations. |
| format | Article |
| id | doaj-art-68ba305fa45b44699bd5801bfb531ace |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-68ba305fa45b44699bd5801bfb531ace2025-08-20T03:15:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15449121544912Case Report: Cutaneous T-cell lymphoma associated with biologic therapy: three cases and a literature reviewTingting Li0Guanyu Wang1Chunlei Zhang2Wenhui Wang3Chunting Li4Yimeng Wang5Department of Dermatology, Peking University Third Hospital, Beijing, ChinaDepartment of Dermatology, Tianjin People's Hospital, Tianjin, ChinaDepartment of Dermatology, Peking University Third Hospital, Beijing, ChinaDepartment of Dermatology, Peking University Third Hospital, Beijing, ChinaDepartment of Dermatology, Peking University Third Hospital, Beijing, ChinaDepartment of Dermatology, Peking University Third Hospital, Beijing, ChinaCutaneous T-cell lymphoma (CTCL) often presents with early-stage clinical features indistinguishable from atopic dermatitis (AD), posing significant diagnostic challenges. Recent studies have highlighted cases where patients initially diagnosed with AD and treated with biologic agents were subsequently reclassified as having CTCL, though the nature of this relationship remains poorly understood. In this report, we present two cases of mycosis fungoides and one case of Sézary syndrome (SS), all initially diagnosed as AD and treated with biologic agents, including dupilumab. Furthermore, we conducted a literature review exploring potential associations between AD, biologic agents, and CTCL. Our objective is to improve clinicians’ ability to differentiate between AD and CTCL and to provide evidence supporting a possible association between biologic treatments and CTCL. Our findings highlight the need for heightened clinical vigilance and the routine use of skin biopsy in refractory eczematous presentations.https://www.frontiersin.org/articles/10.3389/fmed.2025.1544912/fullcutaneous T-cell lymphomabiologicsatopic dermatitisdupilumabJAK inhibitor |
| spellingShingle | Tingting Li Guanyu Wang Chunlei Zhang Wenhui Wang Chunting Li Yimeng Wang Case Report: Cutaneous T-cell lymphoma associated with biologic therapy: three cases and a literature review Frontiers in Medicine cutaneous T-cell lymphoma biologics atopic dermatitis dupilumab JAK inhibitor |
| title | Case Report: Cutaneous T-cell lymphoma associated with biologic therapy: three cases and a literature review |
| title_full | Case Report: Cutaneous T-cell lymphoma associated with biologic therapy: three cases and a literature review |
| title_fullStr | Case Report: Cutaneous T-cell lymphoma associated with biologic therapy: three cases and a literature review |
| title_full_unstemmed | Case Report: Cutaneous T-cell lymphoma associated with biologic therapy: three cases and a literature review |
| title_short | Case Report: Cutaneous T-cell lymphoma associated with biologic therapy: three cases and a literature review |
| title_sort | case report cutaneous t cell lymphoma associated with biologic therapy three cases and a literature review |
| topic | cutaneous T-cell lymphoma biologics atopic dermatitis dupilumab JAK inhibitor |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1544912/full |
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