Epstein-Barr virus induced myositis in a patient with mitochondrial diabetes
Epstein-Barr virus (EBV) is a rare but well-known trigger for acute myositis. Diagnosis is primarily based on the clinical presentation and an accounting laboratory profile. Patients with mitochondrial dysfunction are potentially at a higher risk of myopathic exacerbations upon exposure to acute ins...
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2025-03-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5197 |
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| author | Anna Kyriakidou Anastasia Papapostolou Michalis Picolos |
| author_facet | Anna Kyriakidou Anastasia Papapostolou Michalis Picolos |
| author_sort | Anna Kyriakidou |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV) is a rare but well-known trigger for acute myositis. Diagnosis is primarily based on the clinical presentation and an accounting laboratory profile. Patients with mitochondrial dysfunction are potentially at a higher risk of myopathic exacerbations upon exposure to acute insults. This is due to the high energy requirements of myofibers and their reliance on sufficient mitochondrial performance. Hence, any mitochondrial insult can compromise the function of myofibers. This has implications on the management of people with pre-existing mitochondrial dysfunction, with scope for preventative measures and a lower threshold for diagnosis of myopathies. Usually, management is limited to conservative measures. Medications which predispose to muscle injury need to be withheld during the acute episode and their long-term need reviewed based on a risk-benefit analysis. Here, we present a case of acute EBV-induced myositis on a background of maternally inherited diabetes and deafness and chronic statin intake. |
| format | Article |
| id | doaj-art-68b97b38ec8f44949aa1a768d76d0afd |
| institution | OA Journals |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-68b97b38ec8f44949aa1a768d76d0afd2025-08-20T01:55:18ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-03-0110.12890/2025_0051974732Epstein-Barr virus induced myositis in a patient with mitochondrial diabetesAnna Kyriakidou0https://orcid.org/0000-0001-8964-8345Anastasia Papapostolou1https://orcid.org/0000-0002-6157-2761Michalis Picolos2https://orcid.org/0000-0003-3562-8810Royal Free Foundation Trust, Barnet Hospital, London, UKAlithias Endocrinology Center, Nicosia, Cyprus; European University, Nicosia, CyprusAlithias Endocrinology Center, Nicosia, Cyprus; European University, Nicosia, CyprusEpstein-Barr virus (EBV) is a rare but well-known trigger for acute myositis. Diagnosis is primarily based on the clinical presentation and an accounting laboratory profile. Patients with mitochondrial dysfunction are potentially at a higher risk of myopathic exacerbations upon exposure to acute insults. This is due to the high energy requirements of myofibers and their reliance on sufficient mitochondrial performance. Hence, any mitochondrial insult can compromise the function of myofibers. This has implications on the management of people with pre-existing mitochondrial dysfunction, with scope for preventative measures and a lower threshold for diagnosis of myopathies. Usually, management is limited to conservative measures. Medications which predispose to muscle injury need to be withheld during the acute episode and their long-term need reviewed based on a risk-benefit analysis. Here, we present a case of acute EBV-induced myositis on a background of maternally inherited diabetes and deafness and chronic statin intake.https://www.ejcrim.com/index.php/EJCRIM/article/view/5197mitochondrial diabetesmaternally inherited diabetes and deafnessmiddepstein-barr virusmyositis, statins |
| spellingShingle | Anna Kyriakidou Anastasia Papapostolou Michalis Picolos Epstein-Barr virus induced myositis in a patient with mitochondrial diabetes European Journal of Case Reports in Internal Medicine mitochondrial diabetes maternally inherited diabetes and deafness midd epstein-barr virus myositis, statins |
| title | Epstein-Barr virus induced myositis in a patient with mitochondrial diabetes |
| title_full | Epstein-Barr virus induced myositis in a patient with mitochondrial diabetes |
| title_fullStr | Epstein-Barr virus induced myositis in a patient with mitochondrial diabetes |
| title_full_unstemmed | Epstein-Barr virus induced myositis in a patient with mitochondrial diabetes |
| title_short | Epstein-Barr virus induced myositis in a patient with mitochondrial diabetes |
| title_sort | epstein barr virus induced myositis in a patient with mitochondrial diabetes |
| topic | mitochondrial diabetes maternally inherited diabetes and deafness midd epstein-barr virus myositis, statins |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5197 |
| work_keys_str_mv | AT annakyriakidou epsteinbarrvirusinducedmyositisinapatientwithmitochondrialdiabetes AT anastasiapapapostolou epsteinbarrvirusinducedmyositisinapatientwithmitochondrialdiabetes AT michalispicolos epsteinbarrvirusinducedmyositisinapatientwithmitochondrialdiabetes |