Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?
Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiog...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/516354 |
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| author | Jamshid Vafaeimanesh Seyyed Fakhroldin Hejazi Vahid Damanpak Mostafa Vahedian Mohammadamin Sattari Mohammadreza Seyyedmajidi |
| author_facet | Jamshid Vafaeimanesh Seyyed Fakhroldin Hejazi Vahid Damanpak Mostafa Vahedian Mohammadamin Sattari Mohammadreza Seyyedmajidi |
| author_sort | Jamshid Vafaeimanesh |
| collection | DOAJ |
| description | Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiography. The coronary angiography was performed using Judkins method and patients were assigned to participate in CAD positive (>50% luminal diameter stenosis) and negative groups. The serum HP IgG antibody was checked. Results. Positive and negative CAD groups consisted of 62 and 58 patients, respectively. HP was more prevalent among CAD+ patients, and with increasing the number of coronary arteries with stenosis, the HP seropositivity increased so that 76.3% of patients with multiple vessel diseases (MVD) and 70% of patients with single vessel diseases (SVD) were HP seropositive versus 50% in control group (P=0.006). Positive CAD was significantly associated with HDL level (P=0.01) and ESR level (P=0.006). Also, CAD+ patients had higher CRP levels than controls and it was statistically different between SVD group and controls (P<0.05). Conclusion. HP infection is more prevalent in CAD positive patients and, in case of proving causal relationship, it can be considered as a reversible risk factor for CAD. |
| format | Article |
| id | doaj-art-68b7c7d38a5f4e7eb2490f3dac6a2f8a |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-68b7c7d38a5f4e7eb2490f3dac6a2f8a2025-02-03T01:22:14ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/516354516354Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?Jamshid Vafaeimanesh0Seyyed Fakhroldin Hejazi1Vahid Damanpak2Mostafa Vahedian3Mohammadamin Sattari4Mohammadreza Seyyedmajidi5Clinical Research Development Center, Qom University of Medical Sciences, Qom, IranClinical Research Development Center, Qom University of Medical Sciences, Qom, IranClinical Research Development Center, Qom University of Medical Sciences, Qom, IranClinical Research Development Center, Qom University of Medical Sciences, Qom, IranClinical Research Development Center, Qom University of Medical Sciences, Qom, IranGolestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GOUMS), 10th Azar, 5 Azar Boulevard, Gorgan, Golestan Province, IranBackground. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiography. The coronary angiography was performed using Judkins method and patients were assigned to participate in CAD positive (>50% luminal diameter stenosis) and negative groups. The serum HP IgG antibody was checked. Results. Positive and negative CAD groups consisted of 62 and 58 patients, respectively. HP was more prevalent among CAD+ patients, and with increasing the number of coronary arteries with stenosis, the HP seropositivity increased so that 76.3% of patients with multiple vessel diseases (MVD) and 70% of patients with single vessel diseases (SVD) were HP seropositive versus 50% in control group (P=0.006). Positive CAD was significantly associated with HDL level (P=0.01) and ESR level (P=0.006). Also, CAD+ patients had higher CRP levels than controls and it was statistically different between SVD group and controls (P<0.05). Conclusion. HP infection is more prevalent in CAD positive patients and, in case of proving causal relationship, it can be considered as a reversible risk factor for CAD.http://dx.doi.org/10.1155/2014/516354 |
| spellingShingle | Jamshid Vafaeimanesh Seyyed Fakhroldin Hejazi Vahid Damanpak Mostafa Vahedian Mohammadamin Sattari Mohammadreza Seyyedmajidi Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor? The Scientific World Journal |
| title | Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor? |
| title_full | Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor? |
| title_fullStr | Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor? |
| title_full_unstemmed | Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor? |
| title_short | Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor? |
| title_sort | association of helicobacter pylori infection with coronary artery disease is helicobacter pylori a risk factor |
| url | http://dx.doi.org/10.1155/2014/516354 |
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