The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm
Abstract Previous research suggests that individuals with schizophrenia may exhibit impairments in sensory attenuation. This neurocognitive process is defined as reduced neural responses in sensory cortices to self-generated actions compared with externally triggered sensory inputs. However, the spe...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-07950-2 |
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| author | Weihao Huang Jing Shi Yunhui Ma Yucong Zhang Yongqian Wang Xuteng Wang Yaling Wen Shaokun Zhao Shuping Tan Zhiren Wang |
| author_facet | Weihao Huang Jing Shi Yunhui Ma Yucong Zhang Yongqian Wang Xuteng Wang Yaling Wen Shaokun Zhao Shuping Tan Zhiren Wang |
| author_sort | Weihao Huang |
| collection | DOAJ |
| description | Abstract Previous research suggests that individuals with schizophrenia may exhibit impairments in sensory attenuation. This neurocognitive process is defined as reduced neural responses in sensory cortices to self-generated actions compared with externally triggered sensory inputs. However, the specific neuroimaging association between sensory attenuation deficits and schizophrenia has not been fully established. To elucidate the neuroimaging signatures of these impairments, the present study employed a modified action-outcome contingent paradigm combined with a task-based functional magnetic resonance imaging in 20 individuals with schizophrenia and 21 matched healthy controls. Participants completed voluntary (active) and experimenter-administered (passive) button-press tasks respectively, both eliciting auditory feedback, to isolate the neural correlates of sensory attenuation. Neuroimaging analysis revealed characteristic abnormalities in neural activity within the left middle temporal gyrus/superior temporal gyrus of patients. First, compared to the healthy controls, absence of activation attenuation (passive-active) was observed in these regions under active conditions. This phenomenon suggests a specific impairment in the ability to discriminate self-generated stimuli. Second, when identical auditory stimuli were passively received, significantly lower baseline activation levels within these regions were found in patients than in healthy controls. This task-specific characteristic highlights impaired detection and evaluation of environmentally driven stimuli in patients. |
| format | Article |
| id | doaj-art-68b6de5435e241d5a5faed60e6647bc3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-68b6de5435e241d5a5faed60e6647bc32025-08-20T04:03:03ZengNature PortfolioScientific Reports2045-23222025-07-0115111310.1038/s41598-025-07950-2The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigmWeihao Huang0Jing Shi1Yunhui Ma2Yucong Zhang3Yongqian Wang4Xuteng Wang5Yaling Wen6Shaokun Zhao7Shuping Tan8Zhiren Wang9Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical SchoolAbstract Previous research suggests that individuals with schizophrenia may exhibit impairments in sensory attenuation. This neurocognitive process is defined as reduced neural responses in sensory cortices to self-generated actions compared with externally triggered sensory inputs. However, the specific neuroimaging association between sensory attenuation deficits and schizophrenia has not been fully established. To elucidate the neuroimaging signatures of these impairments, the present study employed a modified action-outcome contingent paradigm combined with a task-based functional magnetic resonance imaging in 20 individuals with schizophrenia and 21 matched healthy controls. Participants completed voluntary (active) and experimenter-administered (passive) button-press tasks respectively, both eliciting auditory feedback, to isolate the neural correlates of sensory attenuation. Neuroimaging analysis revealed characteristic abnormalities in neural activity within the left middle temporal gyrus/superior temporal gyrus of patients. First, compared to the healthy controls, absence of activation attenuation (passive-active) was observed in these regions under active conditions. This phenomenon suggests a specific impairment in the ability to discriminate self-generated stimuli. Second, when identical auditory stimuli were passively received, significantly lower baseline activation levels within these regions were found in patients than in healthy controls. This task-specific characteristic highlights impaired detection and evaluation of environmentally driven stimuli in patients.https://doi.org/10.1038/s41598-025-07950-2SchizophreniaSensory attenuationTemporal gyrusTask-based functional magnetic resonance imagingAction-outcome contingent paradigm |
| spellingShingle | Weihao Huang Jing Shi Yunhui Ma Yucong Zhang Yongqian Wang Xuteng Wang Yaling Wen Shaokun Zhao Shuping Tan Zhiren Wang The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm Scientific Reports Schizophrenia Sensory attenuation Temporal gyrus Task-based functional magnetic resonance imaging Action-outcome contingent paradigm |
| title | The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm |
| title_full | The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm |
| title_fullStr | The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm |
| title_full_unstemmed | The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm |
| title_short | The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm |
| title_sort | neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action outcome contingent paradigm |
| topic | Schizophrenia Sensory attenuation Temporal gyrus Task-based functional magnetic resonance imaging Action-outcome contingent paradigm |
| url | https://doi.org/10.1038/s41598-025-07950-2 |
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