Assessment of the Clinical Profile of Dyspepsia with Predominantly Abdominal Bloating Symptoms in Type 2 Diabetes Mellitus Patients: A Cross-sectional Observational Study
Aim and background: Diabetes mellitus virtually affects every organ in the body. Gastrointestinal effects include small intestinal bacterial overgrowth (SIBO), gastrointestinal reflux disease, gastroparesis, neuropathy, pancreatopathy, and non-alcoholic fatty liver disease. Our study aimed to assess...
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Jaypee Brothers Medical Publisher
2024-12-01
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| Series: | Bengal Physician Journal |
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| Online Access: | https://www.apibpj.com/doi/BPJ/pdf/10.5005/jp-journals-10070-8071 |
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| author | Nidhi Bhutra Ravi Kant Itish Patnaik Vandana K Dhingra |
| author_facet | Nidhi Bhutra Ravi Kant Itish Patnaik Vandana K Dhingra |
| author_sort | Nidhi Bhutra |
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| description | Aim and background: Diabetes mellitus virtually affects every organ in the body. Gastrointestinal effects include small intestinal bacterial overgrowth (SIBO), gastrointestinal reflux disease, gastroparesis, neuropathy, pancreatopathy, and non-alcoholic fatty liver disease. Our study aimed to assess and identify various causes of dyspepsia in type 2 diabetes mellitus (DM) patients.
Materials and methods: After screening the patients for inclusion and exclusion criteria, enrolled participants were subjected to a urea breath test (UBT), glucose hydrogen breath test (HBT), upper gastrointestinal endoscopy (UGIE), pancreatic fecal elastase (PEF), and gastric scintigraphy.
Results: The study revealed that 42.5% of patients had positive UBT for <italic>H. pylori</italic> gastritis, while 37.5% had organic causes of dyspepsia. Pancreatic exocrine insufficiency (PEI) was present in 37.5% of patients, and slow gastric emptying in 12.5% suggested gastroparesis. There was significant negative correlation between HbA1c and pancreatic fecal elastase levels. In 26.8% of patients, no cause of dyspepsia could be identified, 34.2% had dyspepsia secondary to a single etiology; and 26.8% of patients had two underlying etiologies of dyspepsia. In contrast, the remaining had multiple causes of dyspepsia.
Conclusion and clinical significance: The study identified multiple causes of dyspepsia in type 2 diabetic patients in India, with a large proportion having PEI. Further studies are needed to determine if pancreatic enzyme supplementation can alleviate dyspeptic symptoms. In conclusion, dyspepsia in diabetic patients can be attributed to multiple coexisting causes, necessitating etiology-directed management. |
| format | Article |
| id | doaj-art-68b13ef0d84d45ff9a044b24c46484dc |
| institution | DOAJ |
| issn | 2582-1202 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Bengal Physician Journal |
| spelling | doaj-art-68b13ef0d84d45ff9a044b24c46484dc2025-08-20T03:17:26ZengJaypee Brothers Medical PublisherBengal Physician Journal2582-12022024-12-0111312012410.5005/jp-journals-10070-80717Assessment of the Clinical Profile of Dyspepsia with Predominantly Abdominal Bloating Symptoms in Type 2 Diabetes Mellitus Patients: A Cross-sectional Observational StudyNidhi Bhutra0Ravi Kant1https://orcid.org/0000-0003-1144-4478Itish Patnaik2https://orcid.org/0000-0003-2726-3516Vandana K Dhingra3https://orcid.org/0000-0002-3006-8597Department of General Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, IndiaRavi Kant, Department of General Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India, Phone: +91 9870717859Department of Gastroenterology, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, IndiaDepartment of Nuclear Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, IndiaAim and background: Diabetes mellitus virtually affects every organ in the body. Gastrointestinal effects include small intestinal bacterial overgrowth (SIBO), gastrointestinal reflux disease, gastroparesis, neuropathy, pancreatopathy, and non-alcoholic fatty liver disease. Our study aimed to assess and identify various causes of dyspepsia in type 2 diabetes mellitus (DM) patients. Materials and methods: After screening the patients for inclusion and exclusion criteria, enrolled participants were subjected to a urea breath test (UBT), glucose hydrogen breath test (HBT), upper gastrointestinal endoscopy (UGIE), pancreatic fecal elastase (PEF), and gastric scintigraphy. Results: The study revealed that 42.5% of patients had positive UBT for <italic>H. pylori</italic> gastritis, while 37.5% had organic causes of dyspepsia. Pancreatic exocrine insufficiency (PEI) was present in 37.5% of patients, and slow gastric emptying in 12.5% suggested gastroparesis. There was significant negative correlation between HbA1c and pancreatic fecal elastase levels. In 26.8% of patients, no cause of dyspepsia could be identified, 34.2% had dyspepsia secondary to a single etiology; and 26.8% of patients had two underlying etiologies of dyspepsia. In contrast, the remaining had multiple causes of dyspepsia. Conclusion and clinical significance: The study identified multiple causes of dyspepsia in type 2 diabetic patients in India, with a large proportion having PEI. Further studies are needed to determine if pancreatic enzyme supplementation can alleviate dyspeptic symptoms. In conclusion, dyspepsia in diabetic patients can be attributed to multiple coexisting causes, necessitating etiology-directed management.https://www.apibpj.com/doi/BPJ/pdf/10.5005/jp-journals-10070-8071cross-sectional observational studydyspepsiagastrointestinalhba1cpancreatic exocrine insufficiencypeptic ulcer diseasetype 2 diabetes mellitussmall intestinal bacterial overgrowth |
| spellingShingle | Nidhi Bhutra Ravi Kant Itish Patnaik Vandana K Dhingra Assessment of the Clinical Profile of Dyspepsia with Predominantly Abdominal Bloating Symptoms in Type 2 Diabetes Mellitus Patients: A Cross-sectional Observational Study Bengal Physician Journal cross-sectional observational study dyspepsia gastrointestinal hba1c pancreatic exocrine insufficiency peptic ulcer disease type 2 diabetes mellitus small intestinal bacterial overgrowth |
| title | Assessment of the Clinical Profile of Dyspepsia with Predominantly Abdominal Bloating Symptoms in Type 2 Diabetes Mellitus Patients: A Cross-sectional Observational Study |
| title_full | Assessment of the Clinical Profile of Dyspepsia with Predominantly Abdominal Bloating Symptoms in Type 2 Diabetes Mellitus Patients: A Cross-sectional Observational Study |
| title_fullStr | Assessment of the Clinical Profile of Dyspepsia with Predominantly Abdominal Bloating Symptoms in Type 2 Diabetes Mellitus Patients: A Cross-sectional Observational Study |
| title_full_unstemmed | Assessment of the Clinical Profile of Dyspepsia with Predominantly Abdominal Bloating Symptoms in Type 2 Diabetes Mellitus Patients: A Cross-sectional Observational Study |
| title_short | Assessment of the Clinical Profile of Dyspepsia with Predominantly Abdominal Bloating Symptoms in Type 2 Diabetes Mellitus Patients: A Cross-sectional Observational Study |
| title_sort | assessment of the clinical profile of dyspepsia with predominantly abdominal bloating symptoms in type 2 diabetes mellitus patients a cross sectional observational study |
| topic | cross-sectional observational study dyspepsia gastrointestinal hba1c pancreatic exocrine insufficiency peptic ulcer disease type 2 diabetes mellitus small intestinal bacterial overgrowth |
| url | https://www.apibpj.com/doi/BPJ/pdf/10.5005/jp-journals-10070-8071 |
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