Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer

Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer

Abstract Breast cancer (BC) is the most prevalent and highly heterogeneous malignancy affecting females worldwide, and its development is closely linked to metabolic reprogramming. In this study, label-free quantification (LFQ) was used to analyze the protein expression in exosomes secreted by BC dr...

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Bibliographic Details
Main Authors: Yuxin Ji, Ruonan Li, Guohui Tang, Yuhan Xiao, Ruyin Ye, Jiwen Shi, Chenchen Geng, Ruorong Ran, Chengle Zhu, Wenrui Wang, Changjie Chen, Qingling Yang
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cellular and Molecular Life Sciences
Subjects:
Breast cancer
RAB10
Metabolism
Autophagy
Ferroptosis
Online Access:https://doi.org/10.1007/s00018-025-05788-5
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