The potential role of 1,25(OH)2D3 (Active vitamin D3) in modulating macrophage function; implications for chronic obstructive pulmonary disease (COPD)

Abstract Macrophages play an important role in tissue homeostasis, inflammation, and repair, displaying remarkable plasticity by polarising towards pro-inflammatory M1 or anti-inflammatory M2 phenotypes. In chronic obstructive pulmonary disease (COPD), this regulatory balance is disrupted, resulting...

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Bibliographic Details
Main Authors: Hy Thai, Rei Hassanen, Trevor Whittall, Paul Kirkham
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Inflammation
Subjects:
Online Access:https://doi.org/10.1186/s12950-025-00452-y
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