Development of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients

Development of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients

Antibody-mediated rejection (ABMR) is the leading cause of long-term graft loss in pediatric kidney transplantation (KTx). While donor-specific HLA antibodies are established contributors, emerging evidence suggests a role for non-HLA antibodies in ABMR pathogenesis. In this descriptive study, we an...

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Bibliographic Details
Main Authors: Franziska Schmidt, Murielle Verboom, Michael Hallensleben, Alexander Braumann, Jens Drube, Lena Brunkhorst, Dieter Haffner, Anette Melk, Nele Kanzelmeyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Transplant International
Subjects:
non-HLA antibodies
antibody-mediated rejection
pediatric kidney transplantation
graft loss
pediatric kidney failure
Online Access:https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14463/full
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