CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), has gradually become a leading cause of end-stage liver disease as a heterogeneous group of diseases. While the underlying mechanisms of MASLD remain incompletely understo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1535382/full |
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| author | Xinru Jiang Wei Zhao Botao Shen Yumeng Han Kexin Chen |
| author_facet | Xinru Jiang Wei Zhao Botao Shen Yumeng Han Kexin Chen |
| author_sort | Xinru Jiang |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), has gradually become a leading cause of end-stage liver disease as a heterogeneous group of diseases. While the underlying mechanisms of MASLD remain incompletely understood, it is clear that glycolipid metabolism, coupled with subsequent disruptions in hepatic sinusoidal homeostasis and cellular senescence play significant roles in its onset and progression. In recent years, CD47 has been recognized not only as a critical target in cancer therapy but also as a participant in the development of metabolic diseases through complex signaling pathways. Increasing evidence suggests that CD47 is closely associated with the development of MASLD; however, its role in MASLD has not yet been widely explored. Therefore, this review aims to summarize current research on the potential role of CD47 in the pathogenesis of MASLD, particularly in relation to disturbances in glucose and lipid metabolism. |
| format | Article |
| id | doaj-art-68ad6444ef5a4aefb8aca77011d7d36a |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-68ad6444ef5a4aefb8aca77011d7d36a2025-08-20T03:24:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15353821535382CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLDXinru Jiang0Wei Zhao1Botao Shen2Yumeng Han3Kexin Chen4Department of Cardiology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Cardiology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Cardiology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Cardiology, The First Hospital of Jilin University, Changchun, ChinaCore Facility of the First Hospital of Jilin University, Changchun, ChinaMetabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), has gradually become a leading cause of end-stage liver disease as a heterogeneous group of diseases. While the underlying mechanisms of MASLD remain incompletely understood, it is clear that glycolipid metabolism, coupled with subsequent disruptions in hepatic sinusoidal homeostasis and cellular senescence play significant roles in its onset and progression. In recent years, CD47 has been recognized not only as a critical target in cancer therapy but also as a participant in the development of metabolic diseases through complex signaling pathways. Increasing evidence suggests that CD47 is closely associated with the development of MASLD; however, its role in MASLD has not yet been widely explored. Therefore, this review aims to summarize current research on the potential role of CD47 in the pathogenesis of MASLD, particularly in relation to disturbances in glucose and lipid metabolism.https://www.frontiersin.org/articles/10.3389/fendo.2025.1535382/fullCD47MASLDglucose metabolismlipid metabolismmitochondrialhepatic sinusoidal |
| spellingShingle | Xinru Jiang Wei Zhao Botao Shen Yumeng Han Kexin Chen CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD Frontiers in Endocrinology CD47 MASLD glucose metabolism lipid metabolism mitochondrial hepatic sinusoidal |
| title | CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD |
| title_full | CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD |
| title_fullStr | CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD |
| title_full_unstemmed | CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD |
| title_short | CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD |
| title_sort | cd47 mediated regulation of glucose and lipid metabolism implications for the pathogenesis of masld |
| topic | CD47 MASLD glucose metabolism lipid metabolism mitochondrial hepatic sinusoidal |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1535382/full |
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