Review of mechanisms and frontier applications in IL-17A-induced hypertension
The immune system is closely related to hypertension. Hypertension is an immune disorder to a certain extent, and inflammation is the basis of abnormally elevated blood pressure (BP). The accumulation of T cells and their cytokines can increase BP and end organ damage. T cells are activated by antig...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-02-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2025-1159 |
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| author | Li Ruiyuan Guo Lipeng Liang Bin Sun Wei Hai Feng |
| author_facet | Li Ruiyuan Guo Lipeng Liang Bin Sun Wei Hai Feng |
| author_sort | Li Ruiyuan |
| collection | DOAJ |
| description | The immune system is closely related to hypertension. Hypertension is an immune disorder to a certain extent, and inflammation is the basis of abnormally elevated blood pressure (BP). The accumulation of T cells and their cytokines can increase BP and end organ damage. T cells are activated by antigen-presenting cells of the innate immune system or by the influence of a high-sodium diet, the self-environment, or the gut microbiota. These cells produce inflammatory factors and cytokines, such as interleukin-17A (IL-17A) in T helper 17 cells, causing vascular inflammation, hypertension, and target organ damage |
| format | Article |
| id | doaj-art-68a7770ccce6419f861430dc96260dca |
| institution | DOAJ |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-68a7770ccce6419f861430dc96260dca2025-08-20T02:55:21ZengDe GruyterOpen Medicine2391-54632025-02-012012142210.1515/med-2025-1159Review of mechanisms and frontier applications in IL-17A-induced hypertensionLi Ruiyuan0Guo Lipeng1Liang Bin2Sun Wei3Hai Feng4Graduate School of Jinzhou Medical University, Jinzhou, Liaoning, ChinaDepartment of Cardiology, Dalian Third People’s Hospital of Jinzhou Medical University, No. 40 Qianshan Road, Dalian, 116033, Liaoning, ChinaDepartment of Cardiology, Dalian Third People’s Hospital of Jinzhou Medical University, Dalian, 116033, Liaoning, ChinaDepartment of Cardiology, Dalian Third People’s Hospital of Jinzhou Medical University, Dalian, 116033, Liaoning, ChinaDepartment of Critical Care Medicine, Dalian Third People’s Hospital of Jinzhou Medical University, Liaoning, ChinaThe immune system is closely related to hypertension. Hypertension is an immune disorder to a certain extent, and inflammation is the basis of abnormally elevated blood pressure (BP). The accumulation of T cells and their cytokines can increase BP and end organ damage. T cells are activated by antigen-presenting cells of the innate immune system or by the influence of a high-sodium diet, the self-environment, or the gut microbiota. These cells produce inflammatory factors and cytokines, such as interleukin-17A (IL-17A) in T helper 17 cells, causing vascular inflammation, hypertension, and target organ damagehttps://doi.org/10.1515/med-2025-1159hypertensioninterleukin 17aimmunityt helper 17 cellsinflammation |
| spellingShingle | Li Ruiyuan Guo Lipeng Liang Bin Sun Wei Hai Feng Review of mechanisms and frontier applications in IL-17A-induced hypertension Open Medicine hypertension interleukin 17a immunity t helper 17 cells inflammation |
| title | Review of mechanisms and frontier applications in IL-17A-induced hypertension |
| title_full | Review of mechanisms and frontier applications in IL-17A-induced hypertension |
| title_fullStr | Review of mechanisms and frontier applications in IL-17A-induced hypertension |
| title_full_unstemmed | Review of mechanisms and frontier applications in IL-17A-induced hypertension |
| title_short | Review of mechanisms and frontier applications in IL-17A-induced hypertension |
| title_sort | review of mechanisms and frontier applications in il 17a induced hypertension |
| topic | hypertension interleukin 17a immunity t helper 17 cells inflammation |
| url | https://doi.org/10.1515/med-2025-1159 |
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