Association of mitochondrial haplogroup F with physical performance in korean population
Athletic performance is a complex multifactorial trait involving genetic and environmental factors. The heritability of an athlete status was reported to be about 70% in a twin study, and at least 155 genetic markers are known to be related with athlete status. Mitochondrial DNA (mtDNA) encodes esse...
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| Language: | English |
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BioMed Central
2019-03-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2019-17-1-e11.pdf |
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| author | In Wook Hwang Kicheol Kim Eun Ji Choi Han Jun Jin |
| author_facet | In Wook Hwang Kicheol Kim Eun Ji Choi Han Jun Jin |
| author_sort | In Wook Hwang |
| collection | DOAJ |
| description | Athletic performance is a complex multifactorial trait involving genetic and environmental factors. The heritability of an athlete status was reported to be about 70% in a twin study, and at least 155 genetic markers are known to be related with athlete status. Mitochondrial DNA (mtDNA) encodes essential proteins for oxidative phosphorylation, which is related to aerobic capacity. Thus, mtDNA is a candidate marker for determining physical performance. Recent studies have suggested that polymorphisms of mtDNA are associated with athlete status and/or physical performance in various populations. Therefore, we analyzed mtDNA haplogroups to assess their association with the physical performance of Korean population. The 20 mtDNA haplogroups were determined using the SNaPshot assay. Our result showed a significant association of the haplogroup F with athlete status (odds ratio, 3.04; 95% confidence interval, 1.094 to 8.464; p = 0.012). Athletes with haplogroup F (60.64 ± 3.04) also demonstrated a higher Sargent jump than athletes with other haplogroups (54.28 ± 1.23) (p = 0.041). Thus, our data imply that haplogroup F may play a crucial role in the physical performance of Korean athletes. Functional studies with larger sample sizes are necessary to further substantiate these findings. |
| format | Article |
| id | doaj-art-68a20678779f4246ba605369f0c5c259 |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-68a20678779f4246ba605369f0c5c2592025-02-02T09:30:32ZengBioMed CentralGenomics & Informatics2234-07422019-03-0117110.5808/GI.2019.17.1.e11552Association of mitochondrial haplogroup F with physical performance in korean populationIn Wook Hwang0Kicheol Kim1Eun Ji Choi2Han Jun Jin3 Department of Biological Sciences, College of Natural Science, Dankook University, Cheonan 31116, Korea Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA Department of Biological Sciences, College of Natural Science, Dankook University, Cheonan 31116, Korea Department of Biological Sciences, College of Natural Science, Dankook University, Cheonan 31116, KoreaAthletic performance is a complex multifactorial trait involving genetic and environmental factors. The heritability of an athlete status was reported to be about 70% in a twin study, and at least 155 genetic markers are known to be related with athlete status. Mitochondrial DNA (mtDNA) encodes essential proteins for oxidative phosphorylation, which is related to aerobic capacity. Thus, mtDNA is a candidate marker for determining physical performance. Recent studies have suggested that polymorphisms of mtDNA are associated with athlete status and/or physical performance in various populations. Therefore, we analyzed mtDNA haplogroups to assess their association with the physical performance of Korean population. The 20 mtDNA haplogroups were determined using the SNaPshot assay. Our result showed a significant association of the haplogroup F with athlete status (odds ratio, 3.04; 95% confidence interval, 1.094 to 8.464; p = 0.012). Athletes with haplogroup F (60.64 ± 3.04) also demonstrated a higher Sargent jump than athletes with other haplogroups (54.28 ± 1.23) (p = 0.041). Thus, our data imply that haplogroup F may play a crucial role in the physical performance of Korean athletes. Functional studies with larger sample sizes are necessary to further substantiate these findings.http://genominfo.org/upload/pdf/gi-2019-17-1-e11.pdfathleteshaplogroupKorean populationmitochondrial DNAphysical functional performance |
| spellingShingle | In Wook Hwang Kicheol Kim Eun Ji Choi Han Jun Jin Association of mitochondrial haplogroup F with physical performance in korean population Genomics & Informatics athletes haplogroup Korean population mitochondrial DNA physical functional performance |
| title | Association of mitochondrial haplogroup F with physical performance in korean population |
| title_full | Association of mitochondrial haplogroup F with physical performance in korean population |
| title_fullStr | Association of mitochondrial haplogroup F with physical performance in korean population |
| title_full_unstemmed | Association of mitochondrial haplogroup F with physical performance in korean population |
| title_short | Association of mitochondrial haplogroup F with physical performance in korean population |
| title_sort | association of mitochondrial haplogroup f with physical performance in korean population |
| topic | athletes haplogroup Korean population mitochondrial DNA physical functional performance |
| url | http://genominfo.org/upload/pdf/gi-2019-17-1-e11.pdf |
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