Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review

Tuberous sclerosis complex (TSC) is a rare genetic disorder characterized by the presence of benign tumors in many organs. The pathogenic mutation is found in either the TSC1 or TSC2 tumor suppressor genes. The presence of cortical or subcortical tubers is associated with focal epileptiform dischar...

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Main Author: I. Kasiulevičiūtė
Format: Article
Language:English
Published: Vilnius University Press 2023-10-01
Series:Neurologijos seminarai
Subjects:
Online Access:https://www.journals.vu.lt/neurologijos_seminarai/article/view/33257
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author I. Kasiulevičiūtė
author_facet I. Kasiulevičiūtė
author_sort I. Kasiulevičiūtė
collection DOAJ
description Tuberous sclerosis complex (TSC) is a rare genetic disorder characterized by the presence of benign tumors in many organs. The pathogenic mutation is found in either the TSC1 or TSC2 tumor suppressor genes. The presence of cortical or subcortical tubers is associated with focal epileptiform discharges on the electroencephalogram and subclinical seizures prior to the onset of clinical seizures. It is known that epileptic seizures in tuberous sclerosis are very resistant to the treatment, therefore, developmental delay usually occurs. In the last decade, more attention has been paid to early recognition and control of seizures (with vigabatrin or everolimus) in tuberous sclerosis complex, as this is highly correlated with improved developmental and neurological outcomes. The article reviews epilepsy and preventive antiepileptic treatment for tuberous sclerosis complex.
format Article
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institution Kabale University
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publisher Vilnius University Press
record_format Article
series Neurologijos seminarai
spelling doaj-art-689f2ea572cd46748e6c515e462975382025-01-20T18:22:13ZengVilnius University PressNeurologijos seminarai1392-30642424-59172023-10-01262 (92)10.29014/NS.2022.26.9Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature reviewI. Kasiulevičiūtė 0Vilnius University, Lithuania Tuberous sclerosis complex (TSC) is a rare genetic disorder characterized by the presence of benign tumors in many organs. The pathogenic mutation is found in either the TSC1 or TSC2 tumor suppressor genes. The presence of cortical or subcortical tubers is associated with focal epileptiform discharges on the electroencephalogram and subclinical seizures prior to the onset of clinical seizures. It is known that epileptic seizures in tuberous sclerosis are very resistant to the treatment, therefore, developmental delay usually occurs. In the last decade, more attention has been paid to early recognition and control of seizures (with vigabatrin or everolimus) in tuberous sclerosis complex, as this is highly correlated with improved developmental and neurological outcomes. The article reviews epilepsy and preventive antiepileptic treatment for tuberous sclerosis complex. https://www.journals.vu.lt/neurologijos_seminarai/article/view/33257tuberous sclerosis complexepilepsychildrenpreventive treatmentvigabatrin
spellingShingle I. Kasiulevičiūtė
Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review
Neurologijos seminarai
tuberous sclerosis complex
epilepsy
children
preventive treatment
vigabatrin
title Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review
title_full Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review
title_fullStr Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review
title_full_unstemmed Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review
title_short Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review
title_sort epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex literature review
topic tuberous sclerosis complex
epilepsy
children
preventive treatment
vigabatrin
url https://www.journals.vu.lt/neurologijos_seminarai/article/view/33257
work_keys_str_mv AT ikasiuleviciute epilepsyandpreventiveantiepileptictreatmentintuberoussclerosiscomplexliteraturereview