Oral Immunisation With Non‐GMO Surface Displayed SARS‐CoV‐2 Spike Epitopes on Bacteria‐Like Particles Provokes Robust Humoral and Cellular Immune Responses, and Modulated the Gut Microbiome in Mice

Oral Immunisation With Non‐GMO Surface Displayed SARS‐CoV‐2 Spike Epitopes on Bacteria‐Like Particles Provokes Robust Humoral and Cellular Immune Responses, and Modulated the Gut Microbiome in Mice

ABSTRACT The coronavirus disease 2019 (COVID‐19) is a fatal disease caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). To date, several vaccines have been developed to combat the spread of this virus. Mucosal vaccines using food‐grade bacteria, such as Lactobacillus spp., are pr...

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Bibliographic Details
Main Authors: Robie Vasquez, Ji Hoon Song, Remilyn M. Mendoza, In‐Chan Hwang, Bernadette B. Bagon, Lars Engstrand, Valerie Diane Valeriano, Dae‐Kyung Kang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Microbial Biotechnology
Subjects:
bacteria‐like particles
COVID‐19
immune response
lactobacillus
microbiome
mucosal vaccine
Online Access:https://doi.org/10.1111/1751-7915.70073
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