The Nutritional Phenotyping of Idiopathic Pulmonary Fibrosis Through Morphofunctional Assessment: A Bicentric Cross-Sectional Case–Control Study
There is increasing evidence supporting the use of morphofunctional assessment (MFA) as a tool for clinical characterization and decision-making in malnourished patients. MFA enables the diagnosis of malnutrition, sarcopenia, obesity, and cachexia, leading to a novel phenotype-based classification o...
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2025-03-01
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| author | Alicia Sanmartín-Sánchez Rocío Fernández-Jiménez Eva Cabrera-César Francisco Espíldora-Hernández Isabel Vegas-Aguilar María del Mar Amaya-Campos Fiorella Ximena Palmas-Candia Josefina Olivares-Alcolea Víctor José Simón-Frapolli Isabel Cornejo-Pareja Ana Sánchez-García Mora Murri Patricia Guirado-Peláez Álvaro Vidal-Suárez Lourdes Garrido-Sánchez Francisco J. Tinahones Jose Luis Velasco-Garrido Jose Manuel García-Almeida |
| author_facet | Alicia Sanmartín-Sánchez Rocío Fernández-Jiménez Eva Cabrera-César Francisco Espíldora-Hernández Isabel Vegas-Aguilar María del Mar Amaya-Campos Fiorella Ximena Palmas-Candia Josefina Olivares-Alcolea Víctor José Simón-Frapolli Isabel Cornejo-Pareja Ana Sánchez-García Mora Murri Patricia Guirado-Peláez Álvaro Vidal-Suárez Lourdes Garrido-Sánchez Francisco J. Tinahones Jose Luis Velasco-Garrido Jose Manuel García-Almeida |
| author_sort | Alicia Sanmartín-Sánchez |
| collection | DOAJ |
| description | There is increasing evidence supporting the use of morphofunctional assessment (MFA) as a tool for clinical characterization and decision-making in malnourished patients. MFA enables the diagnosis of malnutrition, sarcopenia, obesity, and cachexia, leading to a novel phenotype-based classification of nutritional disorders. Bioelectrical impedance analysis (BIVA), nutritional ultrasound<sup>®</sup> (NU) and computed tomography (CT) are included, along with functional tests like the Timed Up and Go test (TUG). Myoesteatosis, detectable via CT, can occur independently from nutritional phenotypes and has been identified as a significant mortality predictor in idiophatic pulmonary fibrosis (IPF). Our aim is to analyze the prevalence and overlap of nutritional phenotypes in IPF and evaluate the prognostic value of myoesteatosis. Our bicenter cross-sectional study included 82 IPF patients (84.1% male and with a medium age of 71.1 ± 7.35 years). MFA was performed using BIVA, NU, CT at the T12 level (CT-T12), the handgrip strength (HGS) test, and the TUG. CT-T12 BC parameters were analyzed using FocusedON<sup>®</sup> software, while statistical analyses were conducted with JAMOVI version 2.3.22. All four major nutritional phenotypes were represented in our cohort, with significant overlap. A total of 80.5% met the GLIM criteria for malnutrition, 14.6% had cachexia, 17% were sarcopenic, and 28% were obese. Of the obese patients, 70% were also malnourished, while 100% of sarcopenic obese patients (5.9% of total) had malnutrition. A total of 55% of sarcopenic patients with available CT also had myosteatosis, suggesting muscle quality deterioration as a potential driver of functional impairment. The presence of myosteatosis > 15% in T12-CT was an independent predictor of 12-month mortality (HR = 3.13; 95% CI: 1.01–9.70; <i>p</i> = 0.049), with survival rates of 78.1% vs. 96.6% in patients with vs. without myosteatosis, respectively. To conclude, this study underscores the relevance of MFA in the nutritional characterization of patients with IPF, demonstrating its potential to identify specific phenotypes associated with malnutrition, functional impairment, and the presence of <b>myoesteatosis,</b> thereby providing a valuable tool for clinical decision-making. |
| format | Article |
| id | doaj-art-6891ae011b2a4fd78b7aff76f484dfea |
| institution | DOAJ |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-6891ae011b2a4fd78b7aff76f484dfea2025-08-20T03:13:50ZengMDPI AGLife2075-17292025-03-0115451610.3390/life15040516The Nutritional Phenotyping of Idiopathic Pulmonary Fibrosis Through Morphofunctional Assessment: A Bicentric Cross-Sectional Case–Control StudyAlicia Sanmartín-Sánchez0Rocío Fernández-Jiménez1Eva Cabrera-César2Francisco Espíldora-Hernández3Isabel Vegas-Aguilar4María del Mar Amaya-Campos5Fiorella Ximena Palmas-Candia6Josefina Olivares-Alcolea7Víctor José Simón-Frapolli8Isabel Cornejo-Pareja9Ana Sánchez-García10Mora Murri11Patricia Guirado-Peláez12Álvaro Vidal-Suárez13Lourdes Garrido-Sánchez14Francisco J. Tinahones15Jose Luis Velasco-Garrido16Jose Manuel García-Almeida17Department of Endocrinology and Nutrition, Son Espases University Hospital, 07120 Mallorca, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Neumology, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Neumology, Regional University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainEndocrinology and Nutrition Department, Vall D’Hebron University Hospital, 08035 Barcelona, SpainDepartment of Endocrinology and Nutrition, Son Espases University Hospital, 07120 Mallorca, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Neumology, Virgen de la Victoria University Hospital, 29010 Malaga, SpainDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, SpainThere is increasing evidence supporting the use of morphofunctional assessment (MFA) as a tool for clinical characterization and decision-making in malnourished patients. MFA enables the diagnosis of malnutrition, sarcopenia, obesity, and cachexia, leading to a novel phenotype-based classification of nutritional disorders. Bioelectrical impedance analysis (BIVA), nutritional ultrasound<sup>®</sup> (NU) and computed tomography (CT) are included, along with functional tests like the Timed Up and Go test (TUG). Myoesteatosis, detectable via CT, can occur independently from nutritional phenotypes and has been identified as a significant mortality predictor in idiophatic pulmonary fibrosis (IPF). Our aim is to analyze the prevalence and overlap of nutritional phenotypes in IPF and evaluate the prognostic value of myoesteatosis. Our bicenter cross-sectional study included 82 IPF patients (84.1% male and with a medium age of 71.1 ± 7.35 years). MFA was performed using BIVA, NU, CT at the T12 level (CT-T12), the handgrip strength (HGS) test, and the TUG. CT-T12 BC parameters were analyzed using FocusedON<sup>®</sup> software, while statistical analyses were conducted with JAMOVI version 2.3.22. All four major nutritional phenotypes were represented in our cohort, with significant overlap. A total of 80.5% met the GLIM criteria for malnutrition, 14.6% had cachexia, 17% were sarcopenic, and 28% were obese. Of the obese patients, 70% were also malnourished, while 100% of sarcopenic obese patients (5.9% of total) had malnutrition. A total of 55% of sarcopenic patients with available CT also had myosteatosis, suggesting muscle quality deterioration as a potential driver of functional impairment. The presence of myosteatosis > 15% in T12-CT was an independent predictor of 12-month mortality (HR = 3.13; 95% CI: 1.01–9.70; <i>p</i> = 0.049), with survival rates of 78.1% vs. 96.6% in patients with vs. without myosteatosis, respectively. To conclude, this study underscores the relevance of MFA in the nutritional characterization of patients with IPF, demonstrating its potential to identify specific phenotypes associated with malnutrition, functional impairment, and the presence of <b>myoesteatosis,</b> thereby providing a valuable tool for clinical decision-making.https://www.mdpi.com/2075-1729/15/4/516idiopathic pulmonary fibrosismorphofunctional assessmentbody compositionsarcopeniacachexiamyoesteatosis |
| spellingShingle | Alicia Sanmartín-Sánchez Rocío Fernández-Jiménez Eva Cabrera-César Francisco Espíldora-Hernández Isabel Vegas-Aguilar María del Mar Amaya-Campos Fiorella Ximena Palmas-Candia Josefina Olivares-Alcolea Víctor José Simón-Frapolli Isabel Cornejo-Pareja Ana Sánchez-García Mora Murri Patricia Guirado-Peláez Álvaro Vidal-Suárez Lourdes Garrido-Sánchez Francisco J. Tinahones Jose Luis Velasco-Garrido Jose Manuel García-Almeida The Nutritional Phenotyping of Idiopathic Pulmonary Fibrosis Through Morphofunctional Assessment: A Bicentric Cross-Sectional Case–Control Study Life idiopathic pulmonary fibrosis morphofunctional assessment body composition sarcopenia cachexia myoesteatosis |
| title | The Nutritional Phenotyping of Idiopathic Pulmonary Fibrosis Through Morphofunctional Assessment: A Bicentric Cross-Sectional Case–Control Study |
| title_full | The Nutritional Phenotyping of Idiopathic Pulmonary Fibrosis Through Morphofunctional Assessment: A Bicentric Cross-Sectional Case–Control Study |
| title_fullStr | The Nutritional Phenotyping of Idiopathic Pulmonary Fibrosis Through Morphofunctional Assessment: A Bicentric Cross-Sectional Case–Control Study |
| title_full_unstemmed | The Nutritional Phenotyping of Idiopathic Pulmonary Fibrosis Through Morphofunctional Assessment: A Bicentric Cross-Sectional Case–Control Study |
| title_short | The Nutritional Phenotyping of Idiopathic Pulmonary Fibrosis Through Morphofunctional Assessment: A Bicentric Cross-Sectional Case–Control Study |
| title_sort | nutritional phenotyping of idiopathic pulmonary fibrosis through morphofunctional assessment a bicentric cross sectional case control study |
| topic | idiopathic pulmonary fibrosis morphofunctional assessment body composition sarcopenia cachexia myoesteatosis |
| url | https://www.mdpi.com/2075-1729/15/4/516 |
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