Cognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantation
The treatment of patients with hematological malignancies is often complicated by a number of negative side effects, which include mental disorders, among which cognitive impairment occupies a special place. Psychopathological, psychological, neuropsychological, neurophysiological and neurovisual me...
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| Format: | Article |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-07-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/245 |
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| author | D. E. Vybornykh S. Yu. Fedorova S. O. Khrushchev M. Yu. Drokov E. G. Gemdzhian L. A. Kuzmina E. N. Parovichnikova |
| author_facet | D. E. Vybornykh S. Yu. Fedorova S. O. Khrushchev M. Yu. Drokov E. G. Gemdzhian L. A. Kuzmina E. N. Parovichnikova |
| author_sort | D. E. Vybornykh |
| collection | DOAJ |
| description | The treatment of patients with hematological malignancies is often complicated by a number of negative side effects, which include mental disorders, among which cognitive impairment occupies a special place. Psychopathological, psychological, neuropsychological, neurophysiological and neurovisual methods were used to examine 46 patients with various hematological malignancies during periods prior to allo-HSCT, 1-3 months after allo-HSCT, and 6 months after transplantation. When statistical analysis of data was performed correlation and multivariate analyzes. Patients at each stage of the study identified cognitive impairment caused by a combination of risk factors — the presence of a hematological malignancy, the encephalotropic activity of chemotherapy drugs, and mental, neurological disorders. The characteristic and stable dynamics of CN in the post-transplantation period is traced — a sharp decline in cognitive functions in almost all indicators at once in the early post-transplant period with their gradual recovery by 6 months after allo-HSCT. The attitude of patients to cognitive deficiency also changes during the period of treatment: from anozognosic and hyponozognosic at the pre-transplantation stage to hypernosognostic at long-term periods after allo-HSCT. |
| format | Article |
| id | doaj-art-688ea43c3d3347f89ba3fe75fbbbf6a9 |
| institution | DOAJ |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-688ea43c3d3347f89ba3fe75fbbbf6a92025-08-20T03:20:22ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-07-0102203610.31363/2313-7053-2019-2-20-36242Cognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantationD. E. Vybornykh0S. Yu. Fedorova1S. O. Khrushchev2M. Yu. Drokov3E. G. Gemdzhian4L. A. Kuzmina5E. N. Parovichnikova6ФГБУ «НМИЦ гематологии» Минздрава РоссииNational Research Center for HematologyNational Research Center for HematologyNational Research Center for HematologyNational Research Center for HematologyNational Research Center for HematologyNational Research Center for HematologyThe treatment of patients with hematological malignancies is often complicated by a number of negative side effects, which include mental disorders, among which cognitive impairment occupies a special place. Psychopathological, psychological, neuropsychological, neurophysiological and neurovisual methods were used to examine 46 patients with various hematological malignancies during periods prior to allo-HSCT, 1-3 months after allo-HSCT, and 6 months after transplantation. When statistical analysis of data was performed correlation and multivariate analyzes. Patients at each stage of the study identified cognitive impairment caused by a combination of risk factors — the presence of a hematological malignancy, the encephalotropic activity of chemotherapy drugs, and mental, neurological disorders. The characteristic and stable dynamics of CN in the post-transplantation period is traced — a sharp decline in cognitive functions in almost all indicators at once in the early post-transplant period with their gradual recovery by 6 months after allo-HSCT. The attitude of patients to cognitive deficiency also changes during the period of treatment: from anozognosic and hyponozognosic at the pre-transplantation stage to hypernosognostic at long-term periods after allo-HSCT.https://www.bekhterevreview.com/jour/article/view/245cognitive impairmenthematological malignancieshematopoietic stem cells transplantationmental disordersneurological disordersmultivariate analysis |
| spellingShingle | D. E. Vybornykh S. Yu. Fedorova S. O. Khrushchev M. Yu. Drokov E. G. Gemdzhian L. A. Kuzmina E. N. Parovichnikova Cognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantation Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева cognitive impairment hematological malignancies hematopoietic stem cells transplantation mental disorders neurological disorders multivariate analysis |
| title | Cognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantation |
| title_full | Cognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantation |
| title_fullStr | Cognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantation |
| title_full_unstemmed | Cognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantation |
| title_short | Cognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantation |
| title_sort | cognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantation |
| topic | cognitive impairment hematological malignancies hematopoietic stem cells transplantation mental disorders neurological disorders multivariate analysis |
| url | https://www.bekhterevreview.com/jour/article/view/245 |
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