Preparation and Characterization of a Novel Aqueous Dispersion for Enteric Coating of Pantoprazole Sodium Pellets
The purpose of this work was to investigate a novel aqueous dispersion (Eudragit® L100-55) f or e nteric c oating o f drugs. Three different casting solutions, Eudragit® L100-55 aqueous dispersion, Eudragit® L 100-55 o rganic s olution, and Eudragit® L30D-55 aqueous dispersion, were used to prepare...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0035 |
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| author | Han Min Yu Qin Liu Xuerong Hu Fuqiang Yuan Hong |
| author_facet | Han Min Yu Qin Liu Xuerong Hu Fuqiang Yuan Hong |
| author_sort | Han Min |
| collection | DOAJ |
| description | The purpose of this work was to investigate a novel aqueous dispersion (Eudragit® L100-55) f or e nteric c oating o f drugs. Three different casting solutions, Eudragit® L100-55 aqueous dispersion, Eudragit® L 100-55 o rganic s olution, and Eudragit® L30D-55 aqueous dispersion, were used to prepare free films by the casting method. Drug-loaded pellets, prepared by the extrusion-spheronization method, were coated with one of these three coating solutions using the fluidized-bed spray coating technology. Properties of the free films were thoroughly investigated. Films formed by Eudragit® L100-55 aqueous dispersions showed similar properties to those formed by Eudragit® L100-55 organic solution regarding thermodynamic properties, moisture permeability, solubility and acid tolerance ability. Furthermore, the performance of the novel film was better than that formed by Eudragit® L30D-55 aqueous dispersion. Among the three enteric coating solutions, Eudragit® L100- 55 aqueous dispersion will be a promising aqueous dispersion for enteric coating and can be used in the development of enteric-coated preparations. |
| format | Article |
| id | doaj-art-688873514e094bf2b91fc752739f68ee |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-688873514e094bf2b91fc752739f68ee2025-02-02T00:31:54ZengSciendoActa Pharmaceutica1846-95582018-12-0168444145510.2478/acph-2018-0035acph-2018-0035Preparation and Characterization of a Novel Aqueous Dispersion for Enteric Coating of Pantoprazole Sodium PelletsHan Min0Yu Qin1Liu Xuerong2Hu Fuqiang3Yuan Hong4College of Pharmaceutical Sciences Zhejiang University, 866 Yuhangtang Road,Hangzhou310058, ChinaCollege of Pharmaceutical Sciences Zhejiang University, 866 Yuhangtang Road,Hangzhou310058, ChinaCollege of Pharmaceutical Sciences Zhejiang University, 866 Yuhangtang Road,Hangzhou310058, ChinaCollege of Pharmaceutical Sciences Zhejiang University, 866 Yuhangtang Road,Hangzhou310058, ChinaCollege of Pharmaceutical Sciences Zhejiang University, 866 Yuhangtang Road,Hangzhou310058, ChinaThe purpose of this work was to investigate a novel aqueous dispersion (Eudragit® L100-55) f or e nteric c oating o f drugs. Three different casting solutions, Eudragit® L100-55 aqueous dispersion, Eudragit® L 100-55 o rganic s olution, and Eudragit® L30D-55 aqueous dispersion, were used to prepare free films by the casting method. Drug-loaded pellets, prepared by the extrusion-spheronization method, were coated with one of these three coating solutions using the fluidized-bed spray coating technology. Properties of the free films were thoroughly investigated. Films formed by Eudragit® L100-55 aqueous dispersions showed similar properties to those formed by Eudragit® L100-55 organic solution regarding thermodynamic properties, moisture permeability, solubility and acid tolerance ability. Furthermore, the performance of the novel film was better than that formed by Eudragit® L30D-55 aqueous dispersion. Among the three enteric coating solutions, Eudragit® L100- 55 aqueous dispersion will be a promising aqueous dispersion for enteric coating and can be used in the development of enteric-coated preparations.https://doi.org/10.2478/acph-2018-0035aqueous dispersioneudragit® l100-55eudragit ® l30d-55free filmsenteric-coated pelletsacid tolerance ability |
| spellingShingle | Han Min Yu Qin Liu Xuerong Hu Fuqiang Yuan Hong Preparation and Characterization of a Novel Aqueous Dispersion for Enteric Coating of Pantoprazole Sodium Pellets Acta Pharmaceutica aqueous dispersion eudragit® l100-55 eudragit ® l30d-55 free films enteric-coated pellets acid tolerance ability |
| title | Preparation and Characterization of a Novel Aqueous Dispersion for Enteric Coating of Pantoprazole Sodium Pellets |
| title_full | Preparation and Characterization of a Novel Aqueous Dispersion for Enteric Coating of Pantoprazole Sodium Pellets |
| title_fullStr | Preparation and Characterization of a Novel Aqueous Dispersion for Enteric Coating of Pantoprazole Sodium Pellets |
| title_full_unstemmed | Preparation and Characterization of a Novel Aqueous Dispersion for Enteric Coating of Pantoprazole Sodium Pellets |
| title_short | Preparation and Characterization of a Novel Aqueous Dispersion for Enteric Coating of Pantoprazole Sodium Pellets |
| title_sort | preparation and characterization of a novel aqueous dispersion for enteric coating of pantoprazole sodium pellets |
| topic | aqueous dispersion eudragit® l100-55 eudragit ® l30d-55 free films enteric-coated pellets acid tolerance ability |
| url | https://doi.org/10.2478/acph-2018-0035 |
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