Global transcriptome modulation by xenobiotics: the role of alternative splicing in adaptive responses to chemical exposures

Global transcriptome modulation by xenobiotics: the role of alternative splicing in adaptive responses to chemical exposures

Abstract Background Xenobiotic exposures can extensively influence the expression and alternative splicing of drug-metabolizing enzymes, including cytochromes P450 (CYPs), though their transcriptome-wide impact on splicing remains underexplored. This study used a well-characterized splicing event in...

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Bibliographic Details
Main Authors: Andrew J. Annalora, Jacki L. Coburn, Antony Jozic, Patrick L. Iversen, Craig B. Marcus
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Human Genomics
Subjects:
Cytochromes P450
CYPs
Cytochrome P4502B2
Cyp2b2
Methylenedioxybenzenes
Hepatocytes
Online Access:https://doi.org/10.1186/s40246-024-00694-6
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