Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues
While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC) development. Therefore, we sought to determine the clinical relationship between S3F and its receptors, neuropilin-2 (NP-2) an...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2009/730739 |
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| Summary: | While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little
is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC)
development. Therefore, we sought to determine the clinical relationship between S3F
and its receptors, neuropilin-2 (NP-2) and neuropilin-1 (NP-1) with EOC progression.
We analyzed the immunohistological expression of S3F, NP-2, and NP-1 in clinical
specimens of normal ovaries (N), benign cystadenomas (Cy), well-differentiated
adenocarcinomas (WD), poorly-differentiated adenocarcinomas (PD), inclusion cysts
(IC), paraovarian cysts (PC), and fallopian tubes (FT). Tissue sections were evaluated for
staining intensity and percentage of immunoreactive epithelia. We found that expression
of S3F and NP-2 decreased while NP-1 expression increased with EOC progression.
Interestingly, we also found elevated expression of S3F, NP-2, and NP-1 in epithelia of
ICs, PCs, and FT. Our findings indicate that loss or deregulation of semaphorin signaling
may play an important role in EOC development. |
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| ISSN: | 1687-9589 1687-9597 |