Pulmonary alveolar proteinosis: A case report and literature review
Background: Pulmonary alveolar proteinosis (PAP) is a rare disease caused by the accumulation of surfactant in the lung's alveoli, as a result of malfunction in the cleaning function of alveolar macrophages. The major symptoms include cough and dyspnea. Computed tomography scan usually reveals...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2025-03-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/article-1-4397-en.pdf |
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| author | yasaman Sajadi Simin Moudi Ehsan Chogan Mahmood Monadi |
| author_facet | yasaman Sajadi Simin Moudi Ehsan Chogan Mahmood Monadi |
| author_sort | yasaman Sajadi |
| collection | DOAJ |
| description | Background: Pulmonary alveolar proteinosis (PAP) is a rare disease caused by the accumulation of surfactant in the lung's alveoli, as a result of malfunction in the cleaning function of alveolar macrophages. The major symptoms include cough and dyspnea. Computed tomography scan usually reveals crazy-paving pattern. Lung biopsy confirms the diagnosis by showing accumulations of periodic acid-schiff-positive lipoproteinaceous materials.
Case Presentation: In this report, we present a middle-age man with progressive dyspnea on exertion, and frequent cough with no noteworthy medical history. The results of initial examinations and laboratory tests were non-diagnostic, so imaging studies were requested for the patient. After imaging and suspecting PAP as a differential diagnosis due to results of high resolution computed tomography, a transbronchial biopsy was performed to confirm the diagnosis. Then, according to the histopathology reports, the diagnosis of PAP was made. During the biopsy procedure, the patient developed pneumothorax, and accurate treatment approaches were considered for this complication.
Conclusions: In patients with chronic progressive dyspnea and cough, appropriate and timely imaging and other paraclinic investigations must be considered by the physicians. |
| format | Article |
| id | doaj-art-686e656eb6754aa3aae7789151ddcfa9 |
| institution | OA Journals |
| issn | 2008-6164 2008-6172 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj-art-686e656eb6754aa3aae7789151ddcfa92025-08-20T02:25:37ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722025-03-01162362368Pulmonary alveolar proteinosis: A case report and literature reviewyasaman Sajadi0Simin Moudi1Ehsan Chogan2Mahmood Monadi3 Clinical Research Development Unit of Rouhani Hospital, Rouhani Hospital, Babol University of Medical Sciences,Babol,IR.Iran Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences Babol, Iran Clinical Research Development Unit of Rouhani Hospital, Rouhani Hospital, Babol University of Medical Sciences,Babol,IR.Iran Department of Internal Medicine, School of Medicine, Babol University of Medical Sciences, Babol,IR.Iran.Clinical Research Development Unit of Rouhani Hospital, Rouhani Hospital, Babol University of Medical Sciences,Babol,IR.Iran Background: Pulmonary alveolar proteinosis (PAP) is a rare disease caused by the accumulation of surfactant in the lung's alveoli, as a result of malfunction in the cleaning function of alveolar macrophages. The major symptoms include cough and dyspnea. Computed tomography scan usually reveals crazy-paving pattern. Lung biopsy confirms the diagnosis by showing accumulations of periodic acid-schiff-positive lipoproteinaceous materials. Case Presentation: In this report, we present a middle-age man with progressive dyspnea on exertion, and frequent cough with no noteworthy medical history. The results of initial examinations and laboratory tests were non-diagnostic, so imaging studies were requested for the patient. After imaging and suspecting PAP as a differential diagnosis due to results of high resolution computed tomography, a transbronchial biopsy was performed to confirm the diagnosis. Then, according to the histopathology reports, the diagnosis of PAP was made. During the biopsy procedure, the patient developed pneumothorax, and accurate treatment approaches were considered for this complication. Conclusions: In patients with chronic progressive dyspnea and cough, appropriate and timely imaging and other paraclinic investigations must be considered by the physicians.http://caspjim.com/article-1-4397-en.pdfpulmonary alveolar proteinosisbiopsysurfactant |
| spellingShingle | yasaman Sajadi Simin Moudi Ehsan Chogan Mahmood Monadi Pulmonary alveolar proteinosis: A case report and literature review Caspian Journal of Internal Medicine pulmonary alveolar proteinosis biopsy surfactant |
| title | Pulmonary alveolar proteinosis: A case report and
literature review |
| title_full | Pulmonary alveolar proteinosis: A case report and
literature review |
| title_fullStr | Pulmonary alveolar proteinosis: A case report and
literature review |
| title_full_unstemmed | Pulmonary alveolar proteinosis: A case report and
literature review |
| title_short | Pulmonary alveolar proteinosis: A case report and
literature review |
| title_sort | pulmonary alveolar proteinosis a case report and literature review |
| topic | pulmonary alveolar proteinosis biopsy surfactant |
| url | http://caspjim.com/article-1-4397-en.pdf |
| work_keys_str_mv | AT yasamansajadi pulmonaryalveolarproteinosisacasereportandliteraturereview AT siminmoudi pulmonaryalveolarproteinosisacasereportandliteraturereview AT ehsanchogan pulmonaryalveolarproteinosisacasereportandliteraturereview AT mahmoodmonadi pulmonaryalveolarproteinosisacasereportandliteraturereview |