Insertion/deletion polymorphisms in the ΔNp63 promoter are a risk factor for bladder exstrophy epispadias complex.

Insertion/deletion polymorphisms in the ΔNp63 promoter are a risk factor for bladder exstrophy epispadias complex.

Bladder exstrophy epispadias complex (BEEC) is a severe congenital anomaly; however, the genetic and molecular mechanisms underlying the formation of BEEC remain unclear. TP63, a member of TP53 tumor suppressor gene family, is expressed in bladder urothelium and skin over the external genitalia duri...

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Main Authors: Simon Wilkins, Ke Wei Zhang, Istiak Mahfuz, Renaud Quantin, Nancy D'Cruz, John Hutson, Michael Ee, Darius Bagli, Karen Aitken, Fion Nga-Yin Fong, Patrick Kwok-Shing Ng, Stephen Kwok-Wing Tsui, Wendy Yin-Wan Fung, Tahmina Banu, Atul Thakre, Kaid Johar, Enrique Jaureguizar, Long Li, Wei Cheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003070&type=printable
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