The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression

The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression

Abstract The locus coeruleus (LC) noradrenergic (NA) neurons regulate pain and depression through their projections to various downstream nuclei. Although GABAergic (GABA) neurons in and near the LC (LC‐GABA neurons) provide inhibitory synaptic inputs to LC‐NA neurons, it remains unknown whether the...

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Bibliographic Details
Main Authors:	Yuan Gao, Xue Zhang, Xiao‐Juan Liu, Yi‐Ling Sun, Cui Yin, Dong‐Liang Tang, Cheng Xiao, Chunyi Zhou
Format:	Article
Language:	English
Published:	Wiley 2025-07-01
Series:	Advanced Science
Subjects:	depression GABAergic neuron locus coeruleus neuropathic pain noradrenergic neuron ventrolateral periaqueductal gray
Online Access:	https://doi.org/10.1002/advs.202503739
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