Immunomodulatory effects of fucoidan extracted from Sargassum fusiforme in RAW 264.7 macrophages
Sargassum fusiforme, a brown alga, has been traditionally used as an herbal remedy. While previous studies have reported its immunomodulatory properties, the specific immune-modulating effects of fucoidan extracted from S. fusiforme remain underexplored. This study aimed to assess the immune-enhanci...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Fisheries and Aquatic Science
2024-12-01
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| Series: | Fisheries and Aquatic Sciences |
| Subjects: | |
| Online Access: | http://www.e-fas.org/archive/view_article?doi=10.47853/FAS.2024.e77 |
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| Summary: | Sargassum fusiforme, a brown alga, has been traditionally used as an herbal remedy. While previous studies have reported its immunomodulatory properties, the specific immune-modulating effects of fucoidan extracted from S. fusiforme remain underexplored. This study aimed to assess the immune-enhancing properties of S. fusiforme fucoidan (SFF) using the RAW 264.7 macrophage model. SFF significantly increased nitric oxide (NO) production and phagocytic activity at 25–100 μg/mL concentrations, without exhibiting cytotoxicity. RAW 264.7 macrophages treated with SFF adopted a spindle shape with elongated pseudopodia, indicating an activated state. Additionally, SFF upregulated the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), while promoting the secretion of cytokines such as tumor necrosis factor-α, interleukin (IL)-6, and IL-1β in a dose-dependent manner. SFF also promoted the activation of nuclear factor kappa B and mitogen-activated protein kinase signaling pathways. These findings suggest that SFF exhibits potent immunomodulatory activity in the RAW 264.7 macrophage model and holds potential as a functional food to support immune health. |
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| ISSN: | 2234-1757 |