Is Invasive Mucinous Breast Carcinoma A Rare Variant With Neuroendocrine Differentiation?
We want to bring your attention towards the rare variant of breast cancer hence promoting its early detection and screening. The main advantage of early diagnosis is reduced tumor size without distant dissemination at the initial treatment. Neuroendocrine malignancies are heterogenous with neuronal...
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Bahria Univerisy Health Sciences, Campus Karachi
2021-03-01
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| Series: | Journal of Bahria University Medical and Dental College |
| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/450 |
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| author | Ayesha Asghar Aresha Masood Shah |
| author_facet | Ayesha Asghar Aresha Masood Shah |
| author_sort | Ayesha Asghar |
| collection | DOAJ |
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We want to bring your attention towards the rare variant of
breast cancer hence promoting its early detection and
screening. The main advantage of early diagnosis is reduced
tumor size without distant dissemination at the initial
treatment.
Neuroendocrine malignancies are heterogenous with neuronal
and endocrinal properties. Neuroendocrine cells are present
throughout the body and hence neuroendocrine tumors
(NETS) can arise from any anatomic region. Although breast
cancer is the most frequently diagnosed cancer in women,
breast NETS are very rare. With a prevalence of 1-2 cases
per 10,000 women, breast NETS make up only 0.1% of all
breast cancers and less than 1% of all NETS1. In other
histopathological subtypes of breast carcinomas, invasive
ductal carcinoma is the most common breast tumor reported
worldwide of which mucinous (colloid) variant is the rare
histological subtype, accounts for 1-7% of all invasive
carcinomas 2. However, 30% of invasive breast tumor are
seen with nneuroendocrine differentiation, and is most
commonly associated with mucinous and solid papillary
carcinomas and therefore treated similar to another invasive
carcinoma of breast3.
Mucinous carcinoma is well circumcised and have soft
gelatinous consistency. It has two subtypes, pure mucinous
or mixed type. Pure mucinous carcinoma is a rare cancer
which most commonly occur in older women and less than
1% occurs in younger than 35 years of age4. Pure type is
composed of entirely mucinous carcinoma with two further
subtypes, hypocellular and hypercellular variants. Axillary
lymph node involvement is commonly rare. In a study of
Kashiwagi, demographical data of 71 patients with mucinous
carcinoma of the breast have suggests tumor size ranged
from 0.5cm-12.3cm with mean tumor diameter-3.1cm6.
Mucinous carcinoma with neuroendocrine differentiation
shows good prognosis but tumors which are expressed of
HER 2 neu shows negative prognosis and has increased risk
of recurrence and metastasis. Primary neuroendocrine tumors
of breast have worst prognosis due to lack of long-term
survival data hence it's difficult to make a prognosis for this
carcinoma5
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| format | Article |
| id | doaj-art-684c2ea23666477bbc5a49afbd2f9650 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-684c2ea23666477bbc5a49afbd2f96502025-08-20T03:10:54ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822021-03-0110210.51985/JBUMDC2020027Is Invasive Mucinous Breast Carcinoma A Rare Variant With Neuroendocrine Differentiation?Ayesha AsgharAresha Masood Shah We want to bring your attention towards the rare variant of breast cancer hence promoting its early detection and screening. The main advantage of early diagnosis is reduced tumor size without distant dissemination at the initial treatment. Neuroendocrine malignancies are heterogenous with neuronal and endocrinal properties. Neuroendocrine cells are present throughout the body and hence neuroendocrine tumors (NETS) can arise from any anatomic region. Although breast cancer is the most frequently diagnosed cancer in women, breast NETS are very rare. With a prevalence of 1-2 cases per 10,000 women, breast NETS make up only 0.1% of all breast cancers and less than 1% of all NETS1. In other histopathological subtypes of breast carcinomas, invasive ductal carcinoma is the most common breast tumor reported worldwide of which mucinous (colloid) variant is the rare histological subtype, accounts for 1-7% of all invasive carcinomas 2. However, 30% of invasive breast tumor are seen with nneuroendocrine differentiation, and is most commonly associated with mucinous and solid papillary carcinomas and therefore treated similar to another invasive carcinoma of breast3. Mucinous carcinoma is well circumcised and have soft gelatinous consistency. It has two subtypes, pure mucinous or mixed type. Pure mucinous carcinoma is a rare cancer which most commonly occur in older women and less than 1% occurs in younger than 35 years of age4. Pure type is composed of entirely mucinous carcinoma with two further subtypes, hypocellular and hypercellular variants. Axillary lymph node involvement is commonly rare. In a study of Kashiwagi, demographical data of 71 patients with mucinous carcinoma of the breast have suggests tumor size ranged from 0.5cm-12.3cm with mean tumor diameter-3.1cm6. Mucinous carcinoma with neuroendocrine differentiation shows good prognosis but tumors which are expressed of HER 2 neu shows negative prognosis and has increased risk of recurrence and metastasis. Primary neuroendocrine tumors of breast have worst prognosis due to lack of long-term survival data hence it's difficult to make a prognosis for this carcinoma5 https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/450 |
| spellingShingle | Ayesha Asghar Aresha Masood Shah Is Invasive Mucinous Breast Carcinoma A Rare Variant With Neuroendocrine Differentiation? Journal of Bahria University Medical and Dental College |
| title | Is Invasive Mucinous Breast Carcinoma A Rare Variant With Neuroendocrine Differentiation? |
| title_full | Is Invasive Mucinous Breast Carcinoma A Rare Variant With Neuroendocrine Differentiation? |
| title_fullStr | Is Invasive Mucinous Breast Carcinoma A Rare Variant With Neuroendocrine Differentiation? |
| title_full_unstemmed | Is Invasive Mucinous Breast Carcinoma A Rare Variant With Neuroendocrine Differentiation? |
| title_short | Is Invasive Mucinous Breast Carcinoma A Rare Variant With Neuroendocrine Differentiation? |
| title_sort | is invasive mucinous breast carcinoma a rare variant with neuroendocrine differentiation |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/450 |
| work_keys_str_mv | AT ayeshaasghar isinvasivemucinousbreastcarcinomaararevariantwithneuroendocrinedifferentiation AT areshamasoodshah isinvasivemucinousbreastcarcinomaararevariantwithneuroendocrinedifferentiation |