Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment
Circadian rhythms govern physiological activities through the precise modulation of gene expression and biochemical functions. Dysfunction of circadian rhythms is associated with an increased risk of tumor formation, growth, and metastasis, as well as alterations in the gut microbiota (GM) and the t...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2526716 |
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| author | Taoxing Peng Yiqi Wan Yuxuan Sun Yuexiang Ren Fuli Shi Yangfeng Lv Xiangqiong Wen Qiongfeng Chen Xianhe Yang Shan Xu Jianming Li |
| author_facet | Taoxing Peng Yiqi Wan Yuxuan Sun Yuexiang Ren Fuli Shi Yangfeng Lv Xiangqiong Wen Qiongfeng Chen Xianhe Yang Shan Xu Jianming Li |
| author_sort | Taoxing Peng |
| collection | DOAJ |
| description | Circadian rhythms govern physiological activities through the precise modulation of gene expression and biochemical functions. Dysfunction of circadian rhythms is associated with an increased risk of tumor formation, growth, and metastasis, as well as alterations in the gut microbiota (GM) and the tumor microenvironment (TME). Indeed, the intricate regulatory interactions between the circadian system, GM, and TME present a promising area for further exploration. This review, centered on the circadian system, focuses on the dynamics in the GM and the TME driven by circadian dysfunction. Additionally, it places particular emphasis on the interplay between circadian rhythms and GM. The review further explores how this interplay can be therapeutically leveraged to normalize the TME and enhance clinical outcomes. For the first time, the rhythms-microbiota-microenvironment axis is proposed, linking the circadian system, GM, and TME. Circadian dysfunction significantly impacts this axis, leading to disruptions in both the GM and TME. The review also provides the latest insights and innovative therapies from the perspective of the interplay between circadian rhythms and GM. |
| format | Article |
| id | doaj-art-6845dc138dd14a2ea4e901c564767a9b |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-6845dc138dd14a2ea4e901c564767a9b2025-08-20T03:24:26ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2526716Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironmentTaoxing Peng0Yiqi Wan1Yuxuan Sun2Yuexiang Ren3Fuli Shi4Yangfeng Lv5Xiangqiong Wen6Qiongfeng Chen7Xianhe Yang8Shan Xu9Jianming Li10The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaSchool of Basic Medical Sciences, Nanchang University, Nanchang, ChinaDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaCircadian rhythms govern physiological activities through the precise modulation of gene expression and biochemical functions. Dysfunction of circadian rhythms is associated with an increased risk of tumor formation, growth, and metastasis, as well as alterations in the gut microbiota (GM) and the tumor microenvironment (TME). Indeed, the intricate regulatory interactions between the circadian system, GM, and TME present a promising area for further exploration. This review, centered on the circadian system, focuses on the dynamics in the GM and the TME driven by circadian dysfunction. Additionally, it places particular emphasis on the interplay between circadian rhythms and GM. The review further explores how this interplay can be therapeutically leveraged to normalize the TME and enhance clinical outcomes. For the first time, the rhythms-microbiota-microenvironment axis is proposed, linking the circadian system, GM, and TME. Circadian dysfunction significantly impacts this axis, leading to disruptions in both the GM and TME. The review also provides the latest insights and innovative therapies from the perspective of the interplay between circadian rhythms and GM.https://www.tandfonline.com/doi/10.1080/19490976.2025.2526716Circadian rhythmstumor microenvironmentgut microbiotametabolitesrhythms-microbiota-microenvironment axis |
| spellingShingle | Taoxing Peng Yiqi Wan Yuxuan Sun Yuexiang Ren Fuli Shi Yangfeng Lv Xiangqiong Wen Qiongfeng Chen Xianhe Yang Shan Xu Jianming Li Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment Gut Microbes Circadian rhythms tumor microenvironment gut microbiota metabolites rhythms-microbiota-microenvironment axis |
| title | Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment |
| title_full | Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment |
| title_fullStr | Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment |
| title_full_unstemmed | Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment |
| title_short | Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment |
| title_sort | dysfunctional circadian driven dynamics in gut microbiota and tumor microenvironment |
| topic | Circadian rhythms tumor microenvironment gut microbiota metabolites rhythms-microbiota-microenvironment axis |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2526716 |
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