Evaluation of osteoblast response to polyacrylonitrile infused nano-curcumin coated on titanium discs: Invitro study cell culture experimental study
Purpose: The study evaluated the influence of titanium discs, coated with polyacrylonitrile infused curcumin nanofibers on osteoblast activity. Materials and methods: The titanium discs were coated with polyacrylonitrile nanofibers infused with curcumin. MG-63 cell lines were utilized for cell cultu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426824001799 |
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| author | Shilpi Gupta N. Gopi Chander Aravind Bhat K.V. Anitha |
| author_facet | Shilpi Gupta N. Gopi Chander Aravind Bhat K.V. Anitha |
| author_sort | Shilpi Gupta |
| collection | DOAJ |
| description | Purpose: The study evaluated the influence of titanium discs, coated with polyacrylonitrile infused curcumin nanofibers on osteoblast activity. Materials and methods: The titanium discs were coated with polyacrylonitrile nanofibers infused with curcumin. MG-63 cell lines were utilized for cell culture to assess osteoblast morphology upon exposure of curcumin on titanium discs. SEM comparison was made. Lactate Dehydrogenase (LDH) activity was measured after 2 and 7 days and the Alkaline Phosphatase (ALP) activity of the cells was quantified. Results: The results indicated that the coating had a notable impact on mineralization, LDH and ALP activities. Significant differences were observed between uncoated and coated samples. The SEM analysis indicated that curcumin enhanced bone growth when the Ti discs coated with curcumin are implanted in the bone. Conclusion: Polyacrylonitrile infused nano-curcumin fibers coated on titanium discs potentially enhanced osteoblast response and mineralization. |
| format | Article |
| id | doaj-art-684328e4337a40c58f18c760c7414085 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-684328e4337a40c58f18c760c74140852025-02-09T05:00:11ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-01-011515762Evaluation of osteoblast response to polyacrylonitrile infused nano-curcumin coated on titanium discs: Invitro study cell culture experimental studyShilpi Gupta0N. Gopi Chander1Aravind Bhat2K.V. Anitha3Department of Prosthodontics, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, 89, IndiaCorresponding author. SRM Dental College, Bharathi Salai, Ramapuram, Chennai 89, India.; Department of Prosthodontics, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, 89, IndiaDepartment of Prosthodontics, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, 89, IndiaDepartment of Prosthodontics, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, 89, IndiaPurpose: The study evaluated the influence of titanium discs, coated with polyacrylonitrile infused curcumin nanofibers on osteoblast activity. Materials and methods: The titanium discs were coated with polyacrylonitrile nanofibers infused with curcumin. MG-63 cell lines were utilized for cell culture to assess osteoblast morphology upon exposure of curcumin on titanium discs. SEM comparison was made. Lactate Dehydrogenase (LDH) activity was measured after 2 and 7 days and the Alkaline Phosphatase (ALP) activity of the cells was quantified. Results: The results indicated that the coating had a notable impact on mineralization, LDH and ALP activities. Significant differences were observed between uncoated and coated samples. The SEM analysis indicated that curcumin enhanced bone growth when the Ti discs coated with curcumin are implanted in the bone. Conclusion: Polyacrylonitrile infused nano-curcumin fibers coated on titanium discs potentially enhanced osteoblast response and mineralization.http://www.sciencedirect.com/science/article/pii/S2212426824001799CurcuminTitanium discSurface coating |
| spellingShingle | Shilpi Gupta N. Gopi Chander Aravind Bhat K.V. Anitha Evaluation of osteoblast response to polyacrylonitrile infused nano-curcumin coated on titanium discs: Invitro study cell culture experimental study Journal of Oral Biology and Craniofacial Research Curcumin Titanium disc Surface coating |
| title | Evaluation of osteoblast response to polyacrylonitrile infused nano-curcumin coated on titanium discs: Invitro study cell culture experimental study |
| title_full | Evaluation of osteoblast response to polyacrylonitrile infused nano-curcumin coated on titanium discs: Invitro study cell culture experimental study |
| title_fullStr | Evaluation of osteoblast response to polyacrylonitrile infused nano-curcumin coated on titanium discs: Invitro study cell culture experimental study |
| title_full_unstemmed | Evaluation of osteoblast response to polyacrylonitrile infused nano-curcumin coated on titanium discs: Invitro study cell culture experimental study |
| title_short | Evaluation of osteoblast response to polyacrylonitrile infused nano-curcumin coated on titanium discs: Invitro study cell culture experimental study |
| title_sort | evaluation of osteoblast response to polyacrylonitrile infused nano curcumin coated on titanium discs invitro study cell culture experimental study |
| topic | Curcumin Titanium disc Surface coating |
| url | http://www.sciencedirect.com/science/article/pii/S2212426824001799 |
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