HEP14 treatment improves ovarian function in aged mice through mitophagy enhancement and oxidative stress reduction

HEP14 treatment improves ovarian function in aged mice through mitophagy enhancement and oxidative stress reduction

Abstract Ovarian aging profoundly impacts reproductive health and accelerates the overall aging process, yet the development of effective therapeutic strategies remains a formidable challenge. In this study, we report the rejuvenating effects of HEP14, a natural activator of protein kinase C (PKC) p...

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Bibliographic Details
Main Authors: Liming Gui, Jiajia Sun, Qin Zhong, Kan Liu, Qili Sun, Yingtong Di, Helen Picton, Bin Tang, Xiaojiang Hao, Changzhong Li
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08576-w
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