The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide malignancy and the third leading cause of cancer death in patients. Several studies demonstrated that hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, tumor pr...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1065230 |
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| _version_ | 1832549938950569984 |
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| author | Sabrina Bimonte Maddalena Leongito Antonio Barbieri Vitale del Vecchio Michela Falco Aldo Giudice Raffaele Palaia Vittorio Albino Raimondo Di Giacomo Antonella Petrillo Vincenza Granata Francesco Izzo |
| author_facet | Sabrina Bimonte Maddalena Leongito Antonio Barbieri Vitale del Vecchio Michela Falco Aldo Giudice Raffaele Palaia Vittorio Albino Raimondo Di Giacomo Antonella Petrillo Vincenza Granata Francesco Izzo |
| author_sort | Sabrina Bimonte |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide malignancy and the third leading cause of cancer death in patients. Several studies demonstrated that hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, tumor progression, metastasis development, and drug resistance. Despite the extensive research, the underlying mechanisms by which HCSCs are regulated remain still unclear. MicroRNAs (miRNAs) are able to regulate a lot of biological processes such as self-renewal and pluripotency of HCSCs, representing a new promising strategy for treatment of HCC chemotherapy-resistant tumors. In this review, we synthesize the latest findings on therapeutic regulation of HCSCs by miRNAs, in order to highlight the perspective of novel miRNA-based anticancer therapies for HCC treatment. |
| format | Article |
| id | doaj-art-684134c612274279ac820a5c37eea326 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-684134c612274279ac820a5c37eea3262025-02-03T06:08:10ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/10652301065230The Therapeutic Targets of miRNA in Hepatic Cancer Stem CellsSabrina Bimonte0Maddalena Leongito1Antonio Barbieri2Vitale del Vecchio3Michela Falco4Aldo Giudice5Raffaele Palaia6Vittorio Albino7Raimondo Di Giacomo8Antonella Petrillo9Vincenza Granata10Francesco Izzo11Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyAnimal Facility Unit, National Cancer Institute of Naples “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyAnimal Facility Unit, National Cancer Institute of Naples “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyAnimal Facility Unit, National Cancer Institute of Naples “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyEpidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyDivision of Radiology, National Cancer Institute “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyDivision of Radiology, National Cancer Institute “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation” IRCCS, 80131 Naples, ItalyHepatocellular carcinoma (HCC) is the fifth most common cancer worldwide malignancy and the third leading cause of cancer death in patients. Several studies demonstrated that hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, tumor progression, metastasis development, and drug resistance. Despite the extensive research, the underlying mechanisms by which HCSCs are regulated remain still unclear. MicroRNAs (miRNAs) are able to regulate a lot of biological processes such as self-renewal and pluripotency of HCSCs, representing a new promising strategy for treatment of HCC chemotherapy-resistant tumors. In this review, we synthesize the latest findings on therapeutic regulation of HCSCs by miRNAs, in order to highlight the perspective of novel miRNA-based anticancer therapies for HCC treatment.http://dx.doi.org/10.1155/2016/1065230 |
| spellingShingle | Sabrina Bimonte Maddalena Leongito Antonio Barbieri Vitale del Vecchio Michela Falco Aldo Giudice Raffaele Palaia Vittorio Albino Raimondo Di Giacomo Antonella Petrillo Vincenza Granata Francesco Izzo The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells Stem Cells International |
| title | The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells |
| title_full | The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells |
| title_fullStr | The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells |
| title_full_unstemmed | The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells |
| title_short | The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells |
| title_sort | therapeutic targets of mirna in hepatic cancer stem cells |
| url | http://dx.doi.org/10.1155/2016/1065230 |
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