Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism
A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone s...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/7396716 |
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| author | Miriane de Oliveira Bruna Moretto Rodrigues Regiane Marques Castro Olimpio Jones Bernardes Graceli Bianca Mariani Gonçalves Sarah Maria Barneze Costa Tabata Marinda da Silva Maria Teresa De Sibio Fernanda Cristina Fontes Moretto Lucas Solla Mathias Dariane Beatriz Marino Cardoso Helena Paim Tilli Leandro Ceotto Freitas-Lima Celia Regina Nogueira |
| author_facet | Miriane de Oliveira Bruna Moretto Rodrigues Regiane Marques Castro Olimpio Jones Bernardes Graceli Bianca Mariani Gonçalves Sarah Maria Barneze Costa Tabata Marinda da Silva Maria Teresa De Sibio Fernanda Cristina Fontes Moretto Lucas Solla Mathias Dariane Beatriz Marino Cardoso Helena Paim Tilli Leandro Ceotto Freitas-Lima Celia Regina Nogueira |
| author_sort | Miriane de Oliveira |
| collection | DOAJ |
| description | A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone system but can also cause abnormal functions. Thyroid hormone (TH) disruption is defined as an abnormal change in TH production, transport, function, or metabolism, which results in some degree of impairment in body homeostasis. Many EDCs, including organotin compounds (OTCs), are environmental contaminants that are commonly found in antifouling paints used on ships and in several other industrial procedures. OTCs are obesogenic and can disrupt TH metabolism; however, abnormalities in thyroid function resulting from OTC exposure are less well understood. OTCs, one of the most prevalent EDCs that are encountered on a daily basis, modulate the thyroid axis. In most toxicology studies, it has been reported that OTCs might contribute to hypothyroidism. |
| format | Article |
| id | doaj-art-68352abbea864606808f0a472d10595b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-68352abbea864606808f0a472d10595b2025-02-03T01:21:35ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/73967167396716Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to HypothyroidismMiriane de Oliveira0Bruna Moretto Rodrigues1Regiane Marques Castro Olimpio2Jones Bernardes Graceli3Bianca Mariani Gonçalves4Sarah Maria Barneze Costa5Tabata Marinda da Silva6Maria Teresa De Sibio7Fernanda Cristina Fontes Moretto8Lucas Solla Mathias9Dariane Beatriz Marino Cardoso10Helena Paim Tilli11Leandro Ceotto Freitas-Lima12Celia Regina Nogueira13Department of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Morphology, Federal University of Espírito Santo, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilDepartment of Morphology, Federal University of Espírito Santo, BrazilDepartment of Internal Clinic, São Paulo State University (UNESP), Medical School, Botucatu, SP, BrazilA considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone system but can also cause abnormal functions. Thyroid hormone (TH) disruption is defined as an abnormal change in TH production, transport, function, or metabolism, which results in some degree of impairment in body homeostasis. Many EDCs, including organotin compounds (OTCs), are environmental contaminants that are commonly found in antifouling paints used on ships and in several other industrial procedures. OTCs are obesogenic and can disrupt TH metabolism; however, abnormalities in thyroid function resulting from OTC exposure are less well understood. OTCs, one of the most prevalent EDCs that are encountered on a daily basis, modulate the thyroid axis. In most toxicology studies, it has been reported that OTCs might contribute to hypothyroidism.http://dx.doi.org/10.1155/2019/7396716 |
| spellingShingle | Miriane de Oliveira Bruna Moretto Rodrigues Regiane Marques Castro Olimpio Jones Bernardes Graceli Bianca Mariani Gonçalves Sarah Maria Barneze Costa Tabata Marinda da Silva Maria Teresa De Sibio Fernanda Cristina Fontes Moretto Lucas Solla Mathias Dariane Beatriz Marino Cardoso Helena Paim Tilli Leandro Ceotto Freitas-Lima Celia Regina Nogueira Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism International Journal of Endocrinology |
| title | Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism |
| title_full | Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism |
| title_fullStr | Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism |
| title_full_unstemmed | Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism |
| title_short | Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism |
| title_sort | disruptive effect of organotin on thyroid gland function might contribute to hypothyroidism |
| url | http://dx.doi.org/10.1155/2019/7396716 |
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