Lung Cancer Biomarker Identification from Differential Expression Analysis Using RNA-Seq Data for Designing Multitargeted Drugs
Lung cancer presents a global health challenge, demanding exploration of its molecular intricacies for treatment targets. The goal is to delay progression and intervene early, reducing patient burden. Novel biomarkers are urgently needed for early diagnosis. We analysed RNA sequencing on lung cancer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-08-01
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| Series: | Biology and Life Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9976/35/1/2 |
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| author | Syed Naseer Ahmad Shah Rafat Parveen |
| author_facet | Syed Naseer Ahmad Shah Rafat Parveen |
| author_sort | Syed Naseer Ahmad Shah |
| collection | DOAJ |
| description | Lung cancer presents a global health challenge, demanding exploration of its molecular intricacies for treatment targets. The goal is to delay progression and intervene early, reducing patient burden. Novel biomarkers are urgently needed for early diagnosis. We analysed RNA sequencing on lung cancer samples from NCBI’s SRA database. Using Bioconductor in R, we identified key genes, including hub genes TOP2A and TMEM100, crucial for cellular processes. Additionally, FDA-approved drugs are repurposed as multitargeted inhibitors against upregulated genes, validated through simulations. This approach aims to inhibit the function of crucial genes, potentially offering effective treatment for lung cancer within a comprehensive strategy. |
| format | Article |
| id | doaj-art-682c33a03d5a4a2798ddb60934fc9be1 |
| institution | OA Journals |
| issn | 2673-9976 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology and Life Sciences Forum |
| spelling | doaj-art-682c33a03d5a4a2798ddb60934fc9be12025-08-20T02:11:01ZengMDPI AGBiology and Life Sciences Forum2673-99762024-08-01351210.3390/blsf2024035002Lung Cancer Biomarker Identification from Differential Expression Analysis Using RNA-Seq Data for Designing Multitargeted DrugsSyed Naseer Ahmad Shah0Rafat Parveen1Department of Computer Science, Jamia Millia Islamia, New Delhi 110025, IndiaDepartment of Computer Science, Jamia Millia Islamia, New Delhi 110025, IndiaLung cancer presents a global health challenge, demanding exploration of its molecular intricacies for treatment targets. The goal is to delay progression and intervene early, reducing patient burden. Novel biomarkers are urgently needed for early diagnosis. We analysed RNA sequencing on lung cancer samples from NCBI’s SRA database. Using Bioconductor in R, we identified key genes, including hub genes TOP2A and TMEM100, crucial for cellular processes. Additionally, FDA-approved drugs are repurposed as multitargeted inhibitors against upregulated genes, validated through simulations. This approach aims to inhibit the function of crucial genes, potentially offering effective treatment for lung cancer within a comprehensive strategy.https://www.mdpi.com/2673-9976/35/1/2lung cancerRNA-SeqbiomarkersDEGearly diagnosishub genes |
| spellingShingle | Syed Naseer Ahmad Shah Rafat Parveen Lung Cancer Biomarker Identification from Differential Expression Analysis Using RNA-Seq Data for Designing Multitargeted Drugs Biology and Life Sciences Forum lung cancer RNA-Seq biomarkers DEG early diagnosis hub genes |
| title | Lung Cancer Biomarker Identification from Differential Expression Analysis Using RNA-Seq Data for Designing Multitargeted Drugs |
| title_full | Lung Cancer Biomarker Identification from Differential Expression Analysis Using RNA-Seq Data for Designing Multitargeted Drugs |
| title_fullStr | Lung Cancer Biomarker Identification from Differential Expression Analysis Using RNA-Seq Data for Designing Multitargeted Drugs |
| title_full_unstemmed | Lung Cancer Biomarker Identification from Differential Expression Analysis Using RNA-Seq Data for Designing Multitargeted Drugs |
| title_short | Lung Cancer Biomarker Identification from Differential Expression Analysis Using RNA-Seq Data for Designing Multitargeted Drugs |
| title_sort | lung cancer biomarker identification from differential expression analysis using rna seq data for designing multitargeted drugs |
| topic | lung cancer RNA-Seq biomarkers DEG early diagnosis hub genes |
| url | https://www.mdpi.com/2673-9976/35/1/2 |
| work_keys_str_mv | AT syednaseerahmadshah lungcancerbiomarkeridentificationfromdifferentialexpressionanalysisusingrnaseqdatafordesigningmultitargeteddrugs AT rafatparveen lungcancerbiomarkeridentificationfromdifferentialexpressionanalysisusingrnaseqdatafordesigningmultitargeteddrugs |