Impact of preoperative abdominal MRI staging on outcomes for stage II-III colon cancer: a propensity score-matched cohort study
Abstract Objective Preoperative MRI staging offers a noninvasive approach to assess local tumor invasion and distant metastasis. Attention has been paid to investigating the impact of preoperative abdominal MRI staging on the prognosis of patients with stage II-III colon cancer. Methods Patients who...
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2025-08-01
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| Online Access: | https://doi.org/10.1186/s12885-025-14652-5 |
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| author | Maoshu Bai Lizhu Liu Mengmei Liu Xin Liu Tingting Xu Kun Yu Hongjiang Pu Zhenhui Li |
| author_facet | Maoshu Bai Lizhu Liu Mengmei Liu Xin Liu Tingting Xu Kun Yu Hongjiang Pu Zhenhui Li |
| author_sort | Maoshu Bai |
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| description | Abstract Objective Preoperative MRI staging offers a noninvasive approach to assess local tumor invasion and distant metastasis. Attention has been paid to investigating the impact of preoperative abdominal MRI staging on the prognosis of patients with stage II-III colon cancer. Methods Patients who underwent radical resection for stage II-III colon cancer at Yunnan Cancer Hospital between 2008 and 2017 were retrospectively analyzed and divided into preoperative MRI and non-MRI groups. Propensity score matching (PSM) was applied to balance patient characteristics. Overall survival (OS) and Disease-free survival (DFS) were compared using the Kaplan–Meier method and log-rank test. Additionally, Cox regression was used to evaluate the correlation between preoperative MRI and prognosis, and subgroup analyses further compared the two groups. For multivariable analysis, two models were constructed and compared. Results Among 1086 patients included, 29.28% underwent preoperative abdominal MRI. Patients who received preoperative MRI demonstrated better OS (log-rank p = 0.002), particularly those with stage III colon cancer (p < 0.05). After PSM, the MRI group exhibited significantly better 5-year OS (90.0% vs. 82.0%, P = 0.019) and a lower risk of death (HR, 1.66; 95% CI, 1.07–2.56; P = 0.024). Subgroup analysis revealed that the OS of preoperative MRI was significant in stage III patients. However, no significant difference was observed in DFS between the two groups. Furthermore, compared to the MRI group, the non-MRI group showed a statistically significant increased risk in model 1 (OR = 1.63, 95% CI: 1.08–2.44, P = 0.020) and model 2 (OR = 1.79, 95% CI: 1.17—2.73, P = 0.007) in terms of OS. Conclusion Preoperative abdominal MRI significantly enhances OS in patients with stage II-III colon cancer, especially in those with stage III disease. However, the specific role of MRI in treatment planning, as well as the potential impact of different treatment approaches on outcomes, warrants further investigation into the treatment decision-making processes. |
| format | Article |
| id | doaj-art-6826c813d7ea47c1815a8e710277f967 |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj-art-6826c813d7ea47c1815a8e710277f9672025-08-20T04:02:55ZengBMCBMC Cancer1471-24072025-08-0125111510.1186/s12885-025-14652-5Impact of preoperative abdominal MRI staging on outcomes for stage II-III colon cancer: a propensity score-matched cohort studyMaoshu Bai0Lizhu Liu1Mengmei Liu2Xin Liu3Tingting Xu4Kun Yu5Hongjiang Pu6Zhenhui Li7Department of Oncology, Dazhou Integrated Traditional Chinese Medicine and Western Medicine Hospital, Dazhou Second People’s HospitalDepartment of Radiology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterSchool of Public Health, Kunming Medical UniversityMolecular Diagnosis Center, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan Hospital, Yunnan Cancer HospitalDepartment of Oncology, The People’s Hospital of Chuxiong Yi Autonomous PrefectureDepartment of Colorectal Surgery, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan Hospital, Yunnan Cancer HospitalDepartment of Radiology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterDepartment of Radiology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer CenterAbstract Objective Preoperative MRI staging offers a noninvasive approach to assess local tumor invasion and distant metastasis. Attention has been paid to investigating the impact of preoperative abdominal MRI staging on the prognosis of patients with stage II-III colon cancer. Methods Patients who underwent radical resection for stage II-III colon cancer at Yunnan Cancer Hospital between 2008 and 2017 were retrospectively analyzed and divided into preoperative MRI and non-MRI groups. Propensity score matching (PSM) was applied to balance patient characteristics. Overall survival (OS) and Disease-free survival (DFS) were compared using the Kaplan–Meier method and log-rank test. Additionally, Cox regression was used to evaluate the correlation between preoperative MRI and prognosis, and subgroup analyses further compared the two groups. For multivariable analysis, two models were constructed and compared. Results Among 1086 patients included, 29.28% underwent preoperative abdominal MRI. Patients who received preoperative MRI demonstrated better OS (log-rank p = 0.002), particularly those with stage III colon cancer (p < 0.05). After PSM, the MRI group exhibited significantly better 5-year OS (90.0% vs. 82.0%, P = 0.019) and a lower risk of death (HR, 1.66; 95% CI, 1.07–2.56; P = 0.024). Subgroup analysis revealed that the OS of preoperative MRI was significant in stage III patients. However, no significant difference was observed in DFS between the two groups. Furthermore, compared to the MRI group, the non-MRI group showed a statistically significant increased risk in model 1 (OR = 1.63, 95% CI: 1.08–2.44, P = 0.020) and model 2 (OR = 1.79, 95% CI: 1.17—2.73, P = 0.007) in terms of OS. Conclusion Preoperative abdominal MRI significantly enhances OS in patients with stage II-III colon cancer, especially in those with stage III disease. However, the specific role of MRI in treatment planning, as well as the potential impact of different treatment approaches on outcomes, warrants further investigation into the treatment decision-making processes.https://doi.org/10.1186/s12885-025-14652-5Magnetic resonance imagingColon cancerOverall survivalPropensity score matchingMulticollinearity analysis |
| spellingShingle | Maoshu Bai Lizhu Liu Mengmei Liu Xin Liu Tingting Xu Kun Yu Hongjiang Pu Zhenhui Li Impact of preoperative abdominal MRI staging on outcomes for stage II-III colon cancer: a propensity score-matched cohort study BMC Cancer Magnetic resonance imaging Colon cancer Overall survival Propensity score matching Multicollinearity analysis |
| title | Impact of preoperative abdominal MRI staging on outcomes for stage II-III colon cancer: a propensity score-matched cohort study |
| title_full | Impact of preoperative abdominal MRI staging on outcomes for stage II-III colon cancer: a propensity score-matched cohort study |
| title_fullStr | Impact of preoperative abdominal MRI staging on outcomes for stage II-III colon cancer: a propensity score-matched cohort study |
| title_full_unstemmed | Impact of preoperative abdominal MRI staging on outcomes for stage II-III colon cancer: a propensity score-matched cohort study |
| title_short | Impact of preoperative abdominal MRI staging on outcomes for stage II-III colon cancer: a propensity score-matched cohort study |
| title_sort | impact of preoperative abdominal mri staging on outcomes for stage ii iii colon cancer a propensity score matched cohort study |
| topic | Magnetic resonance imaging Colon cancer Overall survival Propensity score matching Multicollinearity analysis |
| url | https://doi.org/10.1186/s12885-025-14652-5 |
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