Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.

Mycobacterium tuberculosis infection accounted for 1.3 million deaths worldwide in 2022. Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB); however, it has limited protective efficacy in adults. In this study, we constructed a recombinant vaccinia virus expressing...

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Main Authors: Eunkyung Shin, Jin-Seung Yun, Young-Ran Lee, Hye-Ran Cha, Soo-Min Kim, Sung-Jae Shin, Sang-Won Lee, Gyung Tae Chung, Dokeun Kim, Jung Sik Yoo, Jong-Seok Kim, Hye-Sook Jeong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0322147
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author Eunkyung Shin
Jin-Seung Yun
Young-Ran Lee
Hye-Ran Cha
Soo-Min Kim
Sung-Jae Shin
Sang-Won Lee
Gyung Tae Chung
Dokeun Kim
Jung Sik Yoo
Jong-Seok Kim
Hye-Sook Jeong
author_facet Eunkyung Shin
Jin-Seung Yun
Young-Ran Lee
Hye-Ran Cha
Soo-Min Kim
Sung-Jae Shin
Sang-Won Lee
Gyung Tae Chung
Dokeun Kim
Jung Sik Yoo
Jong-Seok Kim
Hye-Sook Jeong
author_sort Eunkyung Shin
collection DOAJ
description Mycobacterium tuberculosis infection accounted for 1.3 million deaths worldwide in 2022. Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB); however, it has limited protective efficacy in adults. In this study, we constructed a recombinant vaccinia virus expressing Ag85B from M. tuberculosis using a novel attenuated vaccinia virus (KVAC103). We then analyzed the immunogenicity of prime-boost inoculation strategies using recombinant KVAC103 expressing Ag85B (rKVAC85B) compared to BCG. In both rKVAC85B prime-boost and BCG prime-rKVAC85B boost inoculation regimens, rKVAC85B induced the generation of specific immunoglobulin G (IgG) and secretion of interferon-γ by immune cells. In vitro analysis of Mycobacterium growth inhibition revealed a comparable immune-mediated pattern of outcomes. Furthermore, bacterial loads in the lungs were significantly lower in mice inoculated with the BCG prime-rKVAC85B boost than in the BCG-only group following a rechallenge infection with both H37Rv and HN878 strains of M. tuberculosis. These findings collectively suggest that KVAC103, incorporated into a viral vector, is a promising candidate for the development of a novel TB vaccine platform that is effective against multiple M. tuberculosis strains, including H37Rv and HN878, and that rKVAC85B effectively stimulates immune responses against M. tuberculosis infection.
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spelling doaj-art-68200c2bcf024daf80b2b179bf148cfe2025-08-20T01:54:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01205e032214710.1371/journal.pone.0322147Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.Eunkyung ShinJin-Seung YunYoung-Ran LeeHye-Ran ChaSoo-Min KimSung-Jae ShinSang-Won LeeGyung Tae ChungDokeun KimJung Sik YooJong-Seok KimHye-Sook JeongMycobacterium tuberculosis infection accounted for 1.3 million deaths worldwide in 2022. Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB); however, it has limited protective efficacy in adults. In this study, we constructed a recombinant vaccinia virus expressing Ag85B from M. tuberculosis using a novel attenuated vaccinia virus (KVAC103). We then analyzed the immunogenicity of prime-boost inoculation strategies using recombinant KVAC103 expressing Ag85B (rKVAC85B) compared to BCG. In both rKVAC85B prime-boost and BCG prime-rKVAC85B boost inoculation regimens, rKVAC85B induced the generation of specific immunoglobulin G (IgG) and secretion of interferon-γ by immune cells. In vitro analysis of Mycobacterium growth inhibition revealed a comparable immune-mediated pattern of outcomes. Furthermore, bacterial loads in the lungs were significantly lower in mice inoculated with the BCG prime-rKVAC85B boost than in the BCG-only group following a rechallenge infection with both H37Rv and HN878 strains of M. tuberculosis. These findings collectively suggest that KVAC103, incorporated into a viral vector, is a promising candidate for the development of a novel TB vaccine platform that is effective against multiple M. tuberculosis strains, including H37Rv and HN878, and that rKVAC85B effectively stimulates immune responses against M. tuberculosis infection.https://doi.org/10.1371/journal.pone.0322147
spellingShingle Eunkyung Shin
Jin-Seung Yun
Young-Ran Lee
Hye-Ran Cha
Soo-Min Kim
Sung-Jae Shin
Sang-Won Lee
Gyung Tae Chung
Dokeun Kim
Jung Sik Yoo
Jong-Seok Kim
Hye-Sook Jeong
Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.
PLoS ONE
title Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.
title_full Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.
title_fullStr Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.
title_full_unstemmed Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.
title_short Efficacy and immunogenicity of rKVAC85B in a BCG prime-boost regimen against H37Rv and HN878 Mycobacterium tuberculosis strains.
title_sort efficacy and immunogenicity of rkvac85b in a bcg prime boost regimen against h37rv and hn878 mycobacterium tuberculosis strains
url https://doi.org/10.1371/journal.pone.0322147
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