Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation
Background: Resting-state metrics, such as brain network activity and functional connectivity (FC), are influenced by preceding cognitive tasks, such as memory formation. Brain stimulation can modulate brain network activity and FC during the resting state. However, it is unknown whether it can acut...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Brain Stimulation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X25000919 |
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| author | Danielle Lauren Kurtin Ketevan Alania Edward Rhodes Samuel Vincent Ines R. Violante Nir Grossman |
| author_facet | Danielle Lauren Kurtin Ketevan Alania Edward Rhodes Samuel Vincent Ines R. Violante Nir Grossman |
| author_sort | Danielle Lauren Kurtin |
| collection | DOAJ |
| description | Background: Resting-state metrics, such as brain network activity and functional connectivity (FC), are influenced by preceding cognitive tasks, such as memory formation. Brain stimulation can modulate brain network activity and FC during the resting state. However, it is unknown whether it can acutely modulate activity or FC traces of preceding cognitive tasks. Objectives: We evaluated whether non-invasive temporal interference (TI) stimulation of the hippocampus can modulate hippocampal resting-state FC traces induced by a preceding hippocampally-dependent task. Methods: We collected resting-state functional magnetic resonance imaging (rsfMRI) in twenty healthy participants before and after the performance of an associative memory task. Theta-band TI stimulation of the medial and anterior hippocampus, and sham stimulation were delivered during post-task resting state. We used permutation tests to assess differences in pairwise mutual information functional connectivity (miFC) between pre-task rsfMRI vs post-task sham. In edges with significantly different pre-vs post-task miFC, permutation tests assessed the effect of TI on post-task miFC. Results: MiFC was significantly lower in several functional networks during post-task sham compared to pre-task baseline, including the hippocampal-connected and task-related Anterior Temporal (AT) and Posterior Medial (PM) networks. TI stimulation of the hippocampus during post-task resting state increased the miFC in the hippocampal AT and PM networks as well as other functional networks. Conclusions: Non-invasive TI stimulation of the hippocampus during the resting state acutely modulated FC traces related to preceding hippocampal-dependent memory tasks. |
| format | Article |
| id | doaj-art-681baeee44bd4f678bd381f2f661f3c7 |
| institution | OA Journals |
| issn | 1935-861X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj-art-681baeee44bd4f678bd381f2f661f3c72025-08-20T01:55:27ZengElsevierBrain Stimulation1935-861X2025-05-0118393794710.1016/j.brs.2025.04.010Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulationDanielle Lauren Kurtin0Ketevan Alania1Edward Rhodes2Samuel Vincent3Ines R. Violante4Nir Grossman5Division of Brain Sciences, Imperial College London, London, UK; UK Dementia Research Institute, Imperial College London, London, UK; Corresponding author. Division of Brain Sciences, Imperial College London, London, UK.Division of Brain Sciences, Imperial College London, London, UK; UK Dementia Research Institute, Imperial College London, London, UKDivision of Brain Sciences, Imperial College London, London, UK; UK Dementia Research Institute, Imperial College London, London, UKSt Georges, University of London, London, UKSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK; Corresponding author. School of Biomedical Engineering and Imaging Sciences, King's College London, London, UKDivision of Brain Sciences, Imperial College London, London, UK; UK Dementia Research Institute, Imperial College London, London, UK; Corresponding author. Division of Brain Sciences, Imperial College London, London, UK.Background: Resting-state metrics, such as brain network activity and functional connectivity (FC), are influenced by preceding cognitive tasks, such as memory formation. Brain stimulation can modulate brain network activity and FC during the resting state. However, it is unknown whether it can acutely modulate activity or FC traces of preceding cognitive tasks. Objectives: We evaluated whether non-invasive temporal interference (TI) stimulation of the hippocampus can modulate hippocampal resting-state FC traces induced by a preceding hippocampally-dependent task. Methods: We collected resting-state functional magnetic resonance imaging (rsfMRI) in twenty healthy participants before and after the performance of an associative memory task. Theta-band TI stimulation of the medial and anterior hippocampus, and sham stimulation were delivered during post-task resting state. We used permutation tests to assess differences in pairwise mutual information functional connectivity (miFC) between pre-task rsfMRI vs post-task sham. In edges with significantly different pre-vs post-task miFC, permutation tests assessed the effect of TI on post-task miFC. Results: MiFC was significantly lower in several functional networks during post-task sham compared to pre-task baseline, including the hippocampal-connected and task-related Anterior Temporal (AT) and Posterior Medial (PM) networks. TI stimulation of the hippocampus during post-task resting state increased the miFC in the hippocampal AT and PM networks as well as other functional networks. Conclusions: Non-invasive TI stimulation of the hippocampus during the resting state acutely modulated FC traces related to preceding hippocampal-dependent memory tasks.http://www.sciencedirect.com/science/article/pii/S1935861X25000919Temporal interferenceStimulationHippocampusMemoryFunctional connectivityNetworks |
| spellingShingle | Danielle Lauren Kurtin Ketevan Alania Edward Rhodes Samuel Vincent Ines R. Violante Nir Grossman Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation Brain Stimulation Temporal interference Stimulation Hippocampus Memory Functional connectivity Networks |
| title | Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation |
| title_full | Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation |
| title_fullStr | Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation |
| title_full_unstemmed | Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation |
| title_short | Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation |
| title_sort | task related changes in resting state connectivity are affected by temporal interference ti stimulation |
| topic | Temporal interference Stimulation Hippocampus Memory Functional connectivity Networks |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X25000919 |
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