Optimized enrichment of murine blood–brain barrier vessels with a critical focus on network hierarchy in post-collection analysis

Optimized enrichment of murine blood–brain barrier vessels with a critical focus on network hierarchy in post-collection analysis

Abstract Cerebrovascular networks contain a unique region of interconnected capillaries known as the blood–brain barrier (BBB). Positioned between upstream arteries and downstream veins, these microvessels have unique structural features, such as the absence of vascular smooth muscle cells (vSMCs) a...

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Bibliographic Details
Main Authors: Hanaa Abdelazim, Audra Barnes, James Stupin, Ranah Hasson, Carmen Muñoz-Ballester, Kenneth L. Young, Stefanie Robel, James W. Smyth, Samy Lamouille, John C. Chappell
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Brain
Capillary
Blood–brain barrier
Microvascular isolation
Endothelial cell
Smooth muscle cell
Online Access:https://doi.org/10.1038/s41598-025-99364-3
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