The role and mechanism of fatty acid oxidation in cancer drug resistance
Abstract Cancer is a leading cause of death globally. While drug treatment is the most commonly used method for cancer therapy, it is often hampered by drug resistance. Consequently, the mechanisms of drug resistance in cancer therapy have become a focus of current research. The mechanisms underlyin...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-06-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02554-1 |
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| author | Yun Lei Shuang Cai Jia-Kui Zhang Si-Qi Ding Zhan-He Zhang Chun-Dong Zhang Dong-Qiu Dai Yong-Shuang Li |
| author_facet | Yun Lei Shuang Cai Jia-Kui Zhang Si-Qi Ding Zhan-He Zhang Chun-Dong Zhang Dong-Qiu Dai Yong-Shuang Li |
| author_sort | Yun Lei |
| collection | DOAJ |
| description | Abstract Cancer is a leading cause of death globally. While drug treatment is the most commonly used method for cancer therapy, it is often hampered by drug resistance. Consequently, the mechanisms of drug resistance in cancer therapy have become a focus of current research. The mechanisms underlying cancer drug resistance are complex and may involve genetic mutation, immune escape, and metabolic reprogramming, amongst others. Metabolic reprogramming is an important marker of tumor cells, and an increasing number of studies have shown that cancer drug resistance is correlated with metabolic reprogramming, especially when fatty acid oxidation (FAO) is involved. More importantly, many preclinical studies have shown that when anti-tumor drugs are combined with FAO inhibitors, cancer cell resistance to drugs can be reversed and the effectiveness of tumor therapy is enhanced. This review provides a comprehensive overview of the mechanisms by which FAO leads to cancer resistance as well as potential targets for inhibition of FAO. |
| format | Article |
| id | doaj-art-680c35e3918a4e1aa7d4e79c148a7228 |
| institution | DOAJ |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-680c35e3918a4e1aa7d4e79c148a72282025-08-20T03:20:59ZengNature Publishing GroupCell Death Discovery2058-77162025-06-0111111510.1038/s41420-025-02554-1The role and mechanism of fatty acid oxidation in cancer drug resistanceYun Lei0Shuang Cai1Jia-Kui Zhang2Si-Qi Ding3Zhan-He Zhang4Chun-Dong Zhang5Dong-Qiu Dai6Yong-Shuang Li7Department of Surgical Oncology and 8th General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Gastroenterology, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Surgical Oncology and 8th General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Surgical Oncology and 8th General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Surgical Oncology and 8th General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Surgical Oncology and 8th General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Surgical Oncology and 8th General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Surgical Oncology and 8th General Surgery, The Fourth Affiliated Hospital of China Medical UniversityAbstract Cancer is a leading cause of death globally. While drug treatment is the most commonly used method for cancer therapy, it is often hampered by drug resistance. Consequently, the mechanisms of drug resistance in cancer therapy have become a focus of current research. The mechanisms underlying cancer drug resistance are complex and may involve genetic mutation, immune escape, and metabolic reprogramming, amongst others. Metabolic reprogramming is an important marker of tumor cells, and an increasing number of studies have shown that cancer drug resistance is correlated with metabolic reprogramming, especially when fatty acid oxidation (FAO) is involved. More importantly, many preclinical studies have shown that when anti-tumor drugs are combined with FAO inhibitors, cancer cell resistance to drugs can be reversed and the effectiveness of tumor therapy is enhanced. This review provides a comprehensive overview of the mechanisms by which FAO leads to cancer resistance as well as potential targets for inhibition of FAO.https://doi.org/10.1038/s41420-025-02554-1 |
| spellingShingle | Yun Lei Shuang Cai Jia-Kui Zhang Si-Qi Ding Zhan-He Zhang Chun-Dong Zhang Dong-Qiu Dai Yong-Shuang Li The role and mechanism of fatty acid oxidation in cancer drug resistance Cell Death Discovery |
| title | The role and mechanism of fatty acid oxidation in cancer drug resistance |
| title_full | The role and mechanism of fatty acid oxidation in cancer drug resistance |
| title_fullStr | The role and mechanism of fatty acid oxidation in cancer drug resistance |
| title_full_unstemmed | The role and mechanism of fatty acid oxidation in cancer drug resistance |
| title_short | The role and mechanism of fatty acid oxidation in cancer drug resistance |
| title_sort | role and mechanism of fatty acid oxidation in cancer drug resistance |
| url | https://doi.org/10.1038/s41420-025-02554-1 |
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