Coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirus
Abstract Members of Orthocoronavirinae subfamily are common among avian species and responsible for diseases in poultry. Unfortunately, knowledge of their diversity and potential pathogenic influence in pigeons is so far scarce. This study describes the first determination of a complete genomic sequ...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-03252-9 |
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| author | Ewa Łukaszuk Daria Dziewulska Arvind Varsani Tomasz Stenzel |
| author_facet | Ewa Łukaszuk Daria Dziewulska Arvind Varsani Tomasz Stenzel |
| author_sort | Ewa Łukaszuk |
| collection | DOAJ |
| description | Abstract Members of Orthocoronavirinae subfamily are common among avian species and responsible for diseases in poultry. Unfortunately, knowledge of their diversity and potential pathogenic influence in pigeons is so far scarce. This study describes the first determination of a complete genomic sequence of a member of Gammacoronavirus genus in pigeons, likely representing new species within the Igacovirus subgenus. The newly obtained sequence appears to be closely related to partial gammacoronavirus sequences identified in pigeons from Poland, Spain, Finland and China, which highlights the wide geographical distribution of this virus. Direct quantitative analysis was performed in sampled pigeons to assess the potential connection of the presence of the virus and the occurrence of enteric disease, and while no statistically significant difference in the viral genome copy numbers was found between the diseased and healthy group, the similar detection rate in both groups is noteworthy. This result obtained from the analysis of 153 cloacal swab samples suggests that the presence of the virus likely is not associated with the occurrence of disease in their host. The study accentuates the need to further study the coronaviruses of avian origin especially considering the seemingly often occurrence of asymptomatic coronaviral infections and their broad geographical distribution. |
| format | Article |
| id | doaj-art-6806aa8d600f43f8b67941f86a75be22 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6806aa8d600f43f8b67941f86a75be222025-08-24T11:22:18ZengNature PortfolioScientific Reports2045-23222025-05-0115111010.1038/s41598-025-03252-9Coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirusEwa Łukaszuk0Daria Dziewulska1Arvind Varsani2Tomasz Stenzel3Department of Poultry Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury in OlsztynDepartment of Poultry Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury in OlsztynBiodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State UniversityDepartment of Poultry Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury in OlsztynAbstract Members of Orthocoronavirinae subfamily are common among avian species and responsible for diseases in poultry. Unfortunately, knowledge of their diversity and potential pathogenic influence in pigeons is so far scarce. This study describes the first determination of a complete genomic sequence of a member of Gammacoronavirus genus in pigeons, likely representing new species within the Igacovirus subgenus. The newly obtained sequence appears to be closely related to partial gammacoronavirus sequences identified in pigeons from Poland, Spain, Finland and China, which highlights the wide geographical distribution of this virus. Direct quantitative analysis was performed in sampled pigeons to assess the potential connection of the presence of the virus and the occurrence of enteric disease, and while no statistically significant difference in the viral genome copy numbers was found between the diseased and healthy group, the similar detection rate in both groups is noteworthy. This result obtained from the analysis of 153 cloacal swab samples suggests that the presence of the virus likely is not associated with the occurrence of disease in their host. The study accentuates the need to further study the coronaviruses of avian origin especially considering the seemingly often occurrence of asymptomatic coronaviral infections and their broad geographical distribution.https://doi.org/10.1038/s41598-025-03252-9CoronavirusddPCRGammacoronavirusOxford nanopore sequencingPigeonPhylogenetic analysis |
| spellingShingle | Ewa Łukaszuk Daria Dziewulska Arvind Varsani Tomasz Stenzel Coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirus Scientific Reports Coronavirus ddPCR Gammacoronavirus Oxford nanopore sequencing Pigeon Phylogenetic analysis |
| title | Coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirus |
| title_full | Coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirus |
| title_fullStr | Coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirus |
| title_full_unstemmed | Coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirus |
| title_short | Coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirus |
| title_sort | coronaviruses in diarrheic pigeons and the first determination of the complete genome of a new pigeon gammacoronavirus |
| topic | Coronavirus ddPCR Gammacoronavirus Oxford nanopore sequencing Pigeon Phylogenetic analysis |
| url | https://doi.org/10.1038/s41598-025-03252-9 |
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