In silico metabolic modelling links microbiome-derived metabolites to risk factors of Alzheimer’s disease

In silico metabolic modelling links microbiome-derived metabolites to risk factors of Alzheimer’s disease

The gut microbiome has become increasingly recognized for its role in the pathogenesis of Alzheimer’s disease (AD) and is thought to influence AD pathogenesis via metabolic crosstalk with the host. However, mechanistic pathways connecting the gut microbiome to AD pathogenesis remain unknown. To expl...

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Bibliographic Details
Main Authors: Tim Hensen, Shahzad Ahmad, Gabi Kastenmüller, Robert Kraaij, Mohsen Ghanbari, Arfan Ikram, Rima Kaddurah-Daouk, Ines Thiele
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes Reports
Subjects:
Gut microbiome
metabolic modeling
Alzheimer’s disease
APOE
bile acid metabolism
Online Access:https://www.tandfonline.com/doi/10.1080/29933935.2024.2443171
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