Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies

Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies

Abstract Histone deacetylation represents a significant epigenetic mechanism that involves the removal of acetyl groups from histones, subsequently influencing gene transcription. Overexpression of histone deacetylases (HDACs) is prevalent across various cancer types, positioning HDAC inhibitors as...

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Bibliographic Details
Main Authors: Wanli Zhang, Luqi Ge, Yiwen Zhang, Zhentao Zhang, Wen Zhang, Feifeng Song, Ping Huang, Tong Xu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:European Journal of Medical Research
Subjects:
Histone deacetylase
Histone deacetylase inhibitors
Tumor
Tumor microenvironment
Online Access:https://doi.org/10.1186/s40001-025-02326-8
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