Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies
Abstract Histone deacetylation represents a significant epigenetic mechanism that involves the removal of acetyl groups from histones, subsequently influencing gene transcription. Overexpression of histone deacetylases (HDACs) is prevalent across various cancer types, positioning HDAC inhibitors as...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02326-8 |
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| _version_ | 1823862656687144960 |
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| author | Wanli Zhang Luqi Ge Yiwen Zhang Zhentao Zhang Wen Zhang Feifeng Song Ping Huang Tong Xu |
| author_facet | Wanli Zhang Luqi Ge Yiwen Zhang Zhentao Zhang Wen Zhang Feifeng Song Ping Huang Tong Xu |
| author_sort | Wanli Zhang |
| collection | DOAJ |
| description | Abstract Histone deacetylation represents a significant epigenetic mechanism that involves the removal of acetyl groups from histones, subsequently influencing gene transcription. Overexpression of histone deacetylases (HDACs) is prevalent across various cancer types, positioning HDAC inhibitors as broadly applicable therapeutic agents. These inhibitors are known to enhance tumor immune antigenicity, potentially slowing tumor progression. Furthermore, the tumor microenvironment, which is intricately linked to cancer development, acts as a mediator in the proliferation of numerous cancers and presents a viable target for oncological therapies. This paper primarily explores how HDAC inhibitors can regulate cancer progression via the tumor microenvironment and suppress tumor growth through multiple pathways, in addition to examining the synergistic effects of combined drug therapies involving HDAC inhibitors. |
| format | Article |
| id | doaj-art-680013e48a834fbb8663876cd5ee4e19 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-680013e48a834fbb8663876cd5ee4e192025-02-09T12:26:44ZengBMCEuropean Journal of Medical Research2047-783X2025-02-0130111210.1186/s40001-025-02326-8Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategiesWanli Zhang0Luqi Ge1Yiwen Zhang2Zhentao Zhang3Wen Zhang4Feifeng Song5Ping Huang6Tong Xu7Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of TechnologyDepartment of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of TechnologyCenter for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital(Affiliated People’s Hospital), Hangzhou Medical CollegeDepartment of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of TechnologyDepartment of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of TechnologyCenter for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital(Affiliated People’s Hospital), Hangzhou Medical CollegeCenter for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital(Affiliated People’s Hospital), Hangzhou Medical CollegeCenter for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital(Affiliated People’s Hospital), Hangzhou Medical CollegeAbstract Histone deacetylation represents a significant epigenetic mechanism that involves the removal of acetyl groups from histones, subsequently influencing gene transcription. Overexpression of histone deacetylases (HDACs) is prevalent across various cancer types, positioning HDAC inhibitors as broadly applicable therapeutic agents. These inhibitors are known to enhance tumor immune antigenicity, potentially slowing tumor progression. Furthermore, the tumor microenvironment, which is intricately linked to cancer development, acts as a mediator in the proliferation of numerous cancers and presents a viable target for oncological therapies. This paper primarily explores how HDAC inhibitors can regulate cancer progression via the tumor microenvironment and suppress tumor growth through multiple pathways, in addition to examining the synergistic effects of combined drug therapies involving HDAC inhibitors.https://doi.org/10.1186/s40001-025-02326-8Histone deacetylaseHistone deacetylase inhibitorsTumorTumor microenvironment |
| spellingShingle | Wanli Zhang Luqi Ge Yiwen Zhang Zhentao Zhang Wen Zhang Feifeng Song Ping Huang Tong Xu Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies European Journal of Medical Research Histone deacetylase Histone deacetylase inhibitors Tumor Tumor microenvironment |
| title | Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies |
| title_full | Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies |
| title_fullStr | Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies |
| title_full_unstemmed | Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies |
| title_short | Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies |
| title_sort | targeted intervention of tumor microenvironment with hdac inhibitors and their combination therapy strategies |
| topic | Histone deacetylase Histone deacetylase inhibitors Tumor Tumor microenvironment |
| url | https://doi.org/10.1186/s40001-025-02326-8 |
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