Mitoxantrone and acquired Long-QT Syndrome. Case presentation.
The acquired Long-QT Syndrome can be caused by more than 100 non anti-arrhythmic drugs. These drugs block potassium channels; particularly the IKr which extends the ventricular repolarization beyond 450 ms. This syndrome is associated with ventricular helical tachycardia that could potentially cause...
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| Format: | Article |
| Language: | Spanish |
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Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2009-05-01
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| Series: | Medisur |
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| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/620 |
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| _version_ | 1832577252984881152 |
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| author | Brandy Viera Valdés Lázaro Enrique De la Cruz Aviléz |
| author_facet | Brandy Viera Valdés Lázaro Enrique De la Cruz Aviléz |
| author_sort | Brandy Viera Valdés |
| collection | DOAJ |
| description | The acquired Long-QT Syndrome can be caused by more than 100 non anti-arrhythmic drugs. These drugs block potassium channels; particularly the IKr which extends the ventricular repolarization beyond 450 ms. This syndrome is associated with ventricular helical tachycardia that could potentially cause immediate death. We report a patient with diagnosis of leukaemia who was treated with mitoxantrone and presented syncope. The electrocardiogram showed an interval QTc of 576 ms. After an exclusion diagnosis we concluded that there could be an association with the use of this drug caused by its toxic effects for the cardiac system. Mitoxantrone interferes in ionic transportation through cellular membrane, delays the exit of potassium from the cells and acts in the functioning of ATP asa Na/K altering the ventricular repolarization; however, it is not on the list of drugs that enlarge the QT interval. Our objective with this work is to raise the interest on new reports on this subject, and to establish a more direct causal relation through the evidence derived from new experiences. |
| format | Article |
| id | doaj-art-67f4db8e7a1f4bc8b7d966eb5c546727 |
| institution | Kabale University |
| issn | 1727-897X |
| language | Spanish |
| publishDate | 2009-05-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj-art-67f4db8e7a1f4bc8b7d966eb5c5467272025-01-30T21:28:41ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2009-05-0172124127476Mitoxantrone and acquired Long-QT Syndrome. Case presentation.Brandy Viera Valdés0Lázaro Enrique De la Cruz Aviléz1Hospital Universitario "Dr. Gustavo Aldereguía Lima" CienfuegosHospital Universitario “Dr. Gustavo Aldereguía Lima”. Cienfuegos.The acquired Long-QT Syndrome can be caused by more than 100 non anti-arrhythmic drugs. These drugs block potassium channels; particularly the IKr which extends the ventricular repolarization beyond 450 ms. This syndrome is associated with ventricular helical tachycardia that could potentially cause immediate death. We report a patient with diagnosis of leukaemia who was treated with mitoxantrone and presented syncope. The electrocardiogram showed an interval QTc of 576 ms. After an exclusion diagnosis we concluded that there could be an association with the use of this drug caused by its toxic effects for the cardiac system. Mitoxantrone interferes in ionic transportation through cellular membrane, delays the exit of potassium from the cells and acts in the functioning of ATP asa Na/K altering the ventricular repolarization; however, it is not on the list of drugs that enlarge the QT interval. Our objective with this work is to raise the interest on new reports on this subject, and to establish a more direct causal relation through the evidence derived from new experiences.http://medisur.sld.cu/index.php/medisur/article/view/620mitoxantronasíndrome de qt prolongadosíncope |
| spellingShingle | Brandy Viera Valdés Lázaro Enrique De la Cruz Aviléz Mitoxantrone and acquired Long-QT Syndrome. Case presentation. Medisur mitoxantrona síndrome de qt prolongado síncope |
| title | Mitoxantrone and acquired Long-QT Syndrome. Case presentation. |
| title_full | Mitoxantrone and acquired Long-QT Syndrome. Case presentation. |
| title_fullStr | Mitoxantrone and acquired Long-QT Syndrome. Case presentation. |
| title_full_unstemmed | Mitoxantrone and acquired Long-QT Syndrome. Case presentation. |
| title_short | Mitoxantrone and acquired Long-QT Syndrome. Case presentation. |
| title_sort | mitoxantrone and acquired long qt syndrome case presentation |
| topic | mitoxantrona síndrome de qt prolongado síncope |
| url | http://medisur.sld.cu/index.php/medisur/article/view/620 |
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