Peroxisome Proliferator-Activated Receptor Alpha Target Genes
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. PPARα serves as a molecular target for hypolipidemic fib...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/612089 |
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| _version_ | 1832554909845684224 |
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| author | Maryam Rakhshandehroo Bianca Knoch Michael Müller Sander Kersten |
| author_facet | Maryam Rakhshandehroo Bianca Knoch Michael Müller Sander Kersten |
| author_sort | Maryam Rakhshandehroo |
| collection | DOAJ |
| description | The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. PPARα serves as a molecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPARα binds and is activated by numerous fatty acids and fatty acid-derived compounds. PPARα governs biological processes by altering the expression of a large number of target genes. Accordingly, the specific role of PPARα is directly related to the biological function of its target genes. Here, we present an overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPARα target genes. The emphasis is on gene regulation by PPARα in liver although many of the results likely apply to other organs and tissues as well. |
| format | Article |
| id | doaj-art-67f22a78d330442cb6e399690d635ac8 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-67f22a78d330442cb6e399690d635ac82025-02-03T05:50:10ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/612089612089Peroxisome Proliferator-Activated Receptor Alpha Target GenesMaryam Rakhshandehroo0Bianca Knoch1Michael Müller2Sander Kersten3Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The NetherlandsFood, Metabolism & Microbiology, Food & Textiles Group, AgResearch, Palmerston North 4442, New ZealandNutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The NetherlandsNutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The NetherlandsThe peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. PPARα serves as a molecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPARα binds and is activated by numerous fatty acids and fatty acid-derived compounds. PPARα governs biological processes by altering the expression of a large number of target genes. Accordingly, the specific role of PPARα is directly related to the biological function of its target genes. Here, we present an overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPARα target genes. The emphasis is on gene regulation by PPARα in liver although many of the results likely apply to other organs and tissues as well.http://dx.doi.org/10.1155/2010/612089 |
| spellingShingle | Maryam Rakhshandehroo Bianca Knoch Michael Müller Sander Kersten Peroxisome Proliferator-Activated Receptor Alpha Target Genes PPAR Research |
| title | Peroxisome Proliferator-Activated Receptor Alpha Target Genes |
| title_full | Peroxisome Proliferator-Activated Receptor Alpha Target Genes |
| title_fullStr | Peroxisome Proliferator-Activated Receptor Alpha Target Genes |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptor Alpha Target Genes |
| title_short | Peroxisome Proliferator-Activated Receptor Alpha Target Genes |
| title_sort | peroxisome proliferator activated receptor alpha target genes |
| url | http://dx.doi.org/10.1155/2010/612089 |
| work_keys_str_mv | AT maryamrakhshandehroo peroxisomeproliferatoractivatedreceptoralphatargetgenes AT biancaknoch peroxisomeproliferatoractivatedreceptoralphatargetgenes AT michaelmuller peroxisomeproliferatoractivatedreceptoralphatargetgenes AT sanderkersten peroxisomeproliferatoractivatedreceptoralphatargetgenes |