Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive Chemotherapy
Although malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly a palliative treatment. Clinical data on postcryotherapy MEM patients in a university-affiliated hospital between 2007 and 2011 were evaluated. Survival curve with or without postcryotherapy chemotherapy and pe...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/369739 |
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| author | Yueh-Fu Fang Meng-Heng Hsieh Tsai-Yu Wang Horng-Chyuan Lin Chih-Teng Yu Chun-Liang Chou Shu-Min Lin Chih-Hsi Kuo Fu-Tsai Chung |
| author_facet | Yueh-Fu Fang Meng-Heng Hsieh Tsai-Yu Wang Horng-Chyuan Lin Chih-Teng Yu Chun-Liang Chou Shu-Min Lin Chih-Hsi Kuo Fu-Tsai Chung |
| author_sort | Yueh-Fu Fang |
| collection | DOAJ |
| description | Although malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly a palliative treatment. Clinical data on postcryotherapy MEM patients in a university-affiliated hospital between 2007 and 2011 were evaluated. Survival curve with or without postcryotherapy chemotherapy and performance status (PS) improvement of these subjects were analyzed using the Kaplan-Meier method. There were 59 patients (42 males), with median age of 64 years (range, 51–76, and median performance status of 2 (interquartile range [IQR], 2-3). Postcryotherapy complications included minor bleeding (n=12) and need for multiple procedures (n=10), while outcomes were relief of symptoms (n=51), improved PS (n=45), and ability to receive chemotherapy (n=40). The survival of patients with chemotherapy postcryotherapy was longer than that of patients without such chemotherapy (median, 534 versus 106 days; log-rank test, P=0.007; hazard ratio, 0.25; 95% confidence interval, 0.10–0.69). The survival of patients with PS improvement postcryotherapy was longer than that of patients without PS improvement (median, 406 versus 106 days; log-rank test, P=0.02; hazard ratio, 0.28; 95% confidence interval, 0.10–0.81). Cryotherapy is a feasible treatment for MEM. With better PS after cryotherapy, further chemotherapy becomes possible for patients to improve survival when MEM caused dyspnea and poor PS. |
| format | Article |
| id | doaj-art-67ee3c236657488bbae75833cde2516c |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-67ee3c236657488bbae75833cde2516c2025-08-20T03:33:54ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/369739369739Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive ChemotherapyYueh-Fu Fang0Meng-Heng Hsieh1Tsai-Yu Wang2Horng-Chyuan Lin3Chih-Teng Yu4Chun-Liang Chou5Shu-Min Lin6Chih-Hsi Kuo7Fu-Tsai Chung8Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, TaiwanDepartment of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, TaiwanDepartment of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, TaiwanDepartment of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, TaiwanDepartment of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, TaiwanDepartment of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, TaiwanDepartment of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, TaiwanDepartment of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, TaiwanDepartment of Internal Medicine, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, TaiwanAlthough malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly a palliative treatment. Clinical data on postcryotherapy MEM patients in a university-affiliated hospital between 2007 and 2011 were evaluated. Survival curve with or without postcryotherapy chemotherapy and performance status (PS) improvement of these subjects were analyzed using the Kaplan-Meier method. There were 59 patients (42 males), with median age of 64 years (range, 51–76, and median performance status of 2 (interquartile range [IQR], 2-3). Postcryotherapy complications included minor bleeding (n=12) and need for multiple procedures (n=10), while outcomes were relief of symptoms (n=51), improved PS (n=45), and ability to receive chemotherapy (n=40). The survival of patients with chemotherapy postcryotherapy was longer than that of patients without such chemotherapy (median, 534 versus 106 days; log-rank test, P=0.007; hazard ratio, 0.25; 95% confidence interval, 0.10–0.69). The survival of patients with PS improvement postcryotherapy was longer than that of patients without PS improvement (median, 406 versus 106 days; log-rank test, P=0.02; hazard ratio, 0.28; 95% confidence interval, 0.10–0.81). Cryotherapy is a feasible treatment for MEM. With better PS after cryotherapy, further chemotherapy becomes possible for patients to improve survival when MEM caused dyspnea and poor PS.http://dx.doi.org/10.1155/2014/369739 |
| spellingShingle | Yueh-Fu Fang Meng-Heng Hsieh Tsai-Yu Wang Horng-Chyuan Lin Chih-Teng Yu Chun-Liang Chou Shu-Min Lin Chih-Hsi Kuo Fu-Tsai Chung Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive Chemotherapy The Scientific World Journal |
| title | Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive Chemotherapy |
| title_full | Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive Chemotherapy |
| title_fullStr | Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive Chemotherapy |
| title_full_unstemmed | Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive Chemotherapy |
| title_short | Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive Chemotherapy |
| title_sort | removal of endobronchial malignant mass by cryotherapy improved performance status to receive chemotherapy |
| url | http://dx.doi.org/10.1155/2014/369739 |
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