LCP simulator: An easy-to-use web tool to simulate pattern analysis and enzymatic cleavage of binary linear copolymers

The composition and enzymatic cleavage of binary linear copolymers (LCPs) composed of two different units, such as the glycans chitosan, homogalacturonan, alginate, or hyaluronan, are widely investigated by researchers from various disciplines including biomedicine, material sciences, and biotechnol...

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Bibliographic Details
Main Authors: Margareta J. Hellmann, Bruno M. Moerschbacher, Stefan Cord-Landwehr
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:SoftwareX
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Online Access:http://www.sciencedirect.com/science/article/pii/S2352711025000172
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Summary:The composition and enzymatic cleavage of binary linear copolymers (LCPs) composed of two different units, such as the glycans chitosan, homogalacturonan, alginate, or hyaluronan, are widely investigated by researchers from various disciplines including biomedicine, material sciences, and biotechnology. The LCP Simulator is a user-friendly free web tool available to anyone without registration at https://lcp-simulator.anvil.app. The objective is to provide support for LCP-researchers, including those lacking experience in in silico analyses, by offering a low-threshold possibility to simulate a) the analysis of distributions of the two units within LCPs, and b) the influence of LCP properties on the composition of products after cleavage with enzymes of defined subsite specificities.
ISSN:2352-7110