TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria
The transmembrane-electrostatically localized protons (TELP) theory may represent a complementary development to Mitchell's chemiosmotic theory. The combination of the two together can now excellently explain the energetics in mitochondria. My calculated transmembrane-attractive force between a...
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KeAi Communications Co., Ltd.
2023-01-01
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| Series: | Mitochondrial Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590279223000056 |
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| author | James Weifu Lee |
| author_facet | James Weifu Lee |
| author_sort | James Weifu Lee |
| collection | DOAJ |
| description | The transmembrane-electrostatically localized protons (TELP) theory may represent a complementary development to Mitchell's chemiosmotic theory. The combination of the two together can now excellently explain the energetics in mitochondria. My calculated transmembrane-attractive force between an excess proton and an excess hydroxide explains how TELP may stay within a 1-nm thin layer at the liquid-membrane interface. Consequently, any pH sensor (sEcGFP) located at least 2–3 nm away from the membrane surface will not be able to see TELP. This feature as predicted from the TELP model was observed exactly in the experiment of Rieger et al., 2021. In contrast to their belief “the Δp at ATP synthase is almost negligible under OXPHOS conditions”, I find, when TELP activity is included in the energy calculations, there is plenty of total protonic Gibbs free energy (ΔGT) well above the physiologically required value of −24.5 kJ mol−1 to drive ATP synthesis through FoF1-ATP synthase. |
| format | Article |
| id | doaj-art-67e774a939a64b87b45e810a9280ed9f |
| institution | Kabale University |
| issn | 2590-2792 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Mitochondrial Communications |
| spelling | doaj-art-67e774a939a64b87b45e810a9280ed9f2025-08-20T03:56:14ZengKeAi Communications Co., Ltd.Mitochondrial Communications2590-27922023-01-011627210.1016/j.mitoco.2023.09.001TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondriaJames Weifu Lee0Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA, 23529, USAThe transmembrane-electrostatically localized protons (TELP) theory may represent a complementary development to Mitchell's chemiosmotic theory. The combination of the two together can now excellently explain the energetics in mitochondria. My calculated transmembrane-attractive force between an excess proton and an excess hydroxide explains how TELP may stay within a 1-nm thin layer at the liquid-membrane interface. Consequently, any pH sensor (sEcGFP) located at least 2–3 nm away from the membrane surface will not be able to see TELP. This feature as predicted from the TELP model was observed exactly in the experiment of Rieger et al., 2021. In contrast to their belief “the Δp at ATP synthase is almost negligible under OXPHOS conditions”, I find, when TELP activity is included in the energy calculations, there is plenty of total protonic Gibbs free energy (ΔGT) well above the physiologically required value of −24.5 kJ mol−1 to drive ATP synthesis through FoF1-ATP synthase.http://www.sciencedirect.com/science/article/pii/S2590279223000056Protonic capacitorWater as protonic conductorProton “hops and turns” mechanismExcess protonsTransmembrane-electrostatically localized protons (TELP)Local protonic motive force |
| spellingShingle | James Weifu Lee TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria Mitochondrial Communications Protonic capacitor Water as protonic conductor Proton “hops and turns” mechanism Excess protons Transmembrane-electrostatically localized protons (TELP) Local protonic motive force |
| title | TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria |
| title_full | TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria |
| title_fullStr | TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria |
| title_full_unstemmed | TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria |
| title_short | TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria |
| title_sort | telp theory elucidating the major observations of rieger et al 2021 in mitochondria |
| topic | Protonic capacitor Water as protonic conductor Proton “hops and turns” mechanism Excess protons Transmembrane-electrostatically localized protons (TELP) Local protonic motive force |
| url | http://www.sciencedirect.com/science/article/pii/S2590279223000056 |
| work_keys_str_mv | AT jamesweifulee telptheoryelucidatingthemajorobservationsofriegeretal2021inmitochondria |