Lithocholic acid attenuates DON-induced inflammatory responses via epigenetic regulation of DUSP5 and TRAF5 in porcine intestinal epithelial cells

Lithocholic acid attenuates DON-induced inflammatory responses via epigenetic regulation of DUSP5 and TRAF5 in porcine intestinal epithelial cells

Deoxynivalenol (DON) is the most common mycotoxin that frequently contaminates human food and animal feed, resulting in intestinal diseases and systemic immunosuppression. Lithocholic acid (LCA) exhibits various pharmacological activities. RNA-seq and ChIP-qPCR analysis were used in the current stud...

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Bibliographic Details
Main Authors:	Shiqi Wang, Xiaoxu Peng, Qi Zhu, Sichen Lu, Ping Hu, In Ho Kim, Hao-Yu Liu, Wael Ennab, Madesh Muniyappan, Demin Cai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Veterinary Science
Subjects:	epigenetics histone modification porcine deoxynivalenol lithocholic acid
Online Access:	https://www.frontiersin.org/articles/10.3389/fvets.2025.1493496/full
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