Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature
Acute coronary syndrome (ACS) requires prompt intervention to prevent myocardial ischemia. This case report describes a patient’s clinical journey, highlighting the challenges associated with aspirin intolerance and the necessity of an alternative antithrombotic approach. The patient, who presented...
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| Format: | Article |
| Language: | English |
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National Scientific Medical Center
2025-04-01
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| Series: | Ķazaķstannyṇ Klinikalyķ Medicinasy |
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| Online Access: | https://www.clinmedkaz.org/download/aspirin-intolerance-in-the-setting-of-acute-coronary-syndrome-case-report-and-review-of-literature-16252.pdf |
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| author | Temirbek Janpaizov Ilvira Ibraimova Erlan Zhumagulov Kaisar Dauyey |
| author_facet | Temirbek Janpaizov Ilvira Ibraimova Erlan Zhumagulov Kaisar Dauyey |
| author_sort | Temirbek Janpaizov |
| collection | DOAJ |
| description | Acute coronary syndrome (ACS) requires prompt intervention to prevent myocardial ischemia. This case report describes a patient’s clinical journey, highlighting the challenges associated with aspirin intolerance and the necessity of an alternative antithrombotic approach. The patient, who presented with ACS and a documented history of aspirin-induced asthma and angioedema, was unable to undergo standard dual antiplatelet therapy (DAPT) with aspirin. Given the urgency of intervention and failed prior aspirin desensitization, ticagrelor and rivaroxaban were selected as alternative agents. The patient underwent successful percutaneous coronary intervention (PCI) with stent placement and was managed postoperatively using a modified antithrombotic regimen. The case underscores the importance of individualized therapy in aspirin-intolerant ACS patients and suggests a viable alternative strategy for anticoagulation and platelet inhibition. Patient outcomes were favorable, demonstrating effective ischemic risk mitigation without aspirin-related hypersensitivity reactions. |
| format | Article |
| id | doaj-art-67e0da290d2f42f59ad2dd426056cfe5 |
| institution | Kabale University |
| issn | 1812-2892 2313-1519 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | National Scientific Medical Center |
| record_format | Article |
| series | Ķazaķstannyṇ Klinikalyķ Medicinasy |
| spelling | doaj-art-67e0da290d2f42f59ad2dd426056cfe52025-08-20T03:47:28ZengNational Scientific Medical CenterĶazaķstannyṇ Klinikalyķ Medicinasy1812-28922313-15192025-04-01222616310.23950/jcmk/16252Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of LiteratureTemirbek Janpaizov0Ilvira Ibraimova1Erlan Zhumagulov2Kaisar Dauyey3Department of Interventional Cardiology and Arrhythmology, City Multidisciplinary Hospital No. 2, Astana, KazakhstanDepartment of Medicine, School of Medicine, Nazarbayev University, Astana, KazakhstanDepartment of Interventional Cardiology and Arrhythmology, City Multidisciplinary Hospital No. 2, Astana, KazakhstanDepartment of Medicine, School of Medicine, Nazarbayev University, Astana, KazakhstanAcute coronary syndrome (ACS) requires prompt intervention to prevent myocardial ischemia. This case report describes a patient’s clinical journey, highlighting the challenges associated with aspirin intolerance and the necessity of an alternative antithrombotic approach. The patient, who presented with ACS and a documented history of aspirin-induced asthma and angioedema, was unable to undergo standard dual antiplatelet therapy (DAPT) with aspirin. Given the urgency of intervention and failed prior aspirin desensitization, ticagrelor and rivaroxaban were selected as alternative agents. The patient underwent successful percutaneous coronary intervention (PCI) with stent placement and was managed postoperatively using a modified antithrombotic regimen. The case underscores the importance of individualized therapy in aspirin-intolerant ACS patients and suggests a viable alternative strategy for anticoagulation and platelet inhibition. Patient outcomes were favorable, demonstrating effective ischemic risk mitigation without aspirin-related hypersensitivity reactions.https://www.clinmedkaz.org/download/aspirin-intolerance-in-the-setting-of-acute-coronary-syndrome-case-report-and-review-of-literature-16252.pdfacute coronary syndromeaspirin intolerancepercutaneous coronary intervention |
| spellingShingle | Temirbek Janpaizov Ilvira Ibraimova Erlan Zhumagulov Kaisar Dauyey Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature Ķazaķstannyṇ Klinikalyķ Medicinasy acute coronary syndrome aspirin intolerance percutaneous coronary intervention |
| title | Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature |
| title_full | Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature |
| title_fullStr | Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature |
| title_full_unstemmed | Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature |
| title_short | Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature |
| title_sort | aspirin intolerance in the setting of acute coronary syndrome case report and review of literature |
| topic | acute coronary syndrome aspirin intolerance percutaneous coronary intervention |
| url | https://www.clinmedkaz.org/download/aspirin-intolerance-in-the-setting-of-acute-coronary-syndrome-case-report-and-review-of-literature-16252.pdf |
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